5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine

Base Information

• Chemical Name: 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine
• CAS No.: 265987-42-6
• Molecular Formula: C₃₁H₂₉N₅O₃S₂
• Molecular Weight: 583.735
• Mol file: 265987-42-6.mol

Synonyms:5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine

Chemical Property of 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine

There total 2 articles about 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

5'-O-trityl-2'-deoxyadenosine (66503-49-9) + methyl iodide (74-88-4) → 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine (265987-42-6)

Guidance literature:

With carbon disulfide; sodium hydroxide; In dimethyl sulfoxide;

Reference yield: 96.0%

carbon disulfide (75-15-0,12122-00-8) + 5'-O-trityl-2'-deoxyadenosine (66503-49-9) + methyl iodide (74-88-4) → 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine (265987-42-6)

Guidance literature:

carbon disulfide; 5'-O-trityl-2'-deoxyadenosine; With sodium hydroxide; In dimethyl sulfoxide;

methyl iodide;

DOI:10.1016/S0040-4039(01)01617-3

Reference yield: 79.0%

5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine (265987-42-6) → 5'-O-trityl-2',3'-dideoxy-adenosine

Guidance literature:

With 2,2'-azobis(isobutyronitrile); hypophosphorous acid; triethylamine; In 1,2-dimethoxyethane; for 1h; Heating;

DOI:10.1016/S0040-4039(01)01617-3

upstream raw materials:

carbon disulfide

5'-O-trityl-2'-deoxyadenosine

methyl iodide