Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-

Base Information

Chemical Name:Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-
CAS No.:874350-06-8
Molecular Formula:C39H54O4S2Si2
Molecular Weight:707.158
Hs Code.:

Cyclohexanone,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil
yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-

Synonyms:

Suppliers and Price of Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-

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Technology Process of Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)-

There total 5 articles about Cyclohexanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-2-hydroxy-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-, (2S,3R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 874350-10-4
(1R,2R,4R,6R)-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-1-[(2-phenyl-1,3-dithian-2-yl)methyl]-cyclohexan-1,6-diol

: 874350-06-8
(2S,3R,5S)-3-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-2-hydroxycyclohexan-1-one

Guidance literature:: With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; at 20 ℃; for 24h;
DOI:10.1002/chem.200500640

Reference yield:

: (4R,6R,8R)-8-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-1-oxaspiro[2.5]octan-4-ol

: 874350-06-8
(2S,3R,5S)-3-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-2-hydroxycyclohexan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / imidazole / dimethylformamide / 3 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -40 °C

2.2: 90 percent / tetrahydrofuran; hexane / 1.75 h / -78 - -45 °C

3.1: 82 percent / aq. AcOH / tetrahydrofuran / 14 h / 20 °C

4.1: 92 percent / dicyclohexylcarbodiimide; DMSO; pyridine / CF₃COOH / benzene / 24 h / 20 °C

With pyridine; 1H-imidazole; n-butyllithium; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/chem.200500640

Reference yield:

: 874350-08-0
(3R,4R,6R,8R)-8-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-4-(trimethylsilyloxy)-1-oxaspiro[2.5]octane

: 874350-06-8
(2S,3R,5S)-3-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-2-[(2-phenyl-1,3-dithian-2-yl)methyl]-2-hydroxycyclohexan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -40 °C

1.2: 90 percent / tetrahydrofuran; hexane / 1.75 h / -78 - -45 °C

2.1: 82 percent / aq. AcOH / tetrahydrofuran / 14 h / 20 °C

3.1: 92 percent / dicyclohexylcarbodiimide; DMSO; pyridine / CF₃COOH / benzene / 24 h / 20 °C

With pyridine; n-butyllithium; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; hexane; benzene;
DOI:10.1002/chem.200500640