Phosphonium, (4-hydroxybutyl)triphenyl-, bromide

Base Information

• Chemical Name: Phosphonium, (4-hydroxybutyl)triphenyl-, bromide
• CAS No.: 87436-78-0
• Molecular Formula: C22H24OP.Br
• Molecular Weight: 415.31
• DSSTox Substance ID: DTXSID40469990
• Mol file: 87436-78-0.mol

Synonyms:87436-78-0;(4-Hydroxybutyl)triphenylphosphonium bromide;Phosphonium, (4-hydroxybutyl)triphenyl-, bromide;SCHEMBL9810148;DTXSID40469990

Chemical Property of Phosphonium, (4-hydroxybutyl)triphenyl-, bromide

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 414.07481
• Heavy Atom Count: 25
• Complexity: 292

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[P+](CCCCO)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]

Technology Process of Phosphonium, (4-hydroxybutyl)triphenyl-, bromide

There total 2 articles about Phosphonium, (4-hydroxybutyl)triphenyl-, bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(4-bromobutoxy)-tert-butyldimethylsilane (89043-32-3) + triphenylphosphine (603-35-0) → (4-hydroxybutyl)-triphenylphosphonium bromide (87436-78-0)

Guidance literature:

In toluene; at 150 ℃; for 19.5h;

DOI:10.1248/cpb.53.1333

Reference yield: 21.0%

4-Bromo-1-butanol (33036-62-3) + triphenylphosphine (603-35-0) → (4-hydroxybutyl)-triphenylphosphonium bromide (87436-78-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 7h; Heating;

DOI:10.1021/ja00287a040

Reference yield: 82.0%

(4-hydroxybutyl)-triphenylphosphonium bromide (87436-78-0) + 2-methylphenyl aldehyde (529-20-4) → (E)-5-o-tolylpent-4-en-1-ol (105337-73-3,117324-69-3)

Guidance literature:

(4-hydroxybutyl)-triphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

2-methylphenyl aldehyde; In tetrahydrofuran; at -20 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c2cc38436a

upstream raw materials:

4-Bromo-1-butanol

triphenylphosphine

(4-bromobutoxy)-tert-butyldimethylsilane

Downstream raw materials:

(E)-4-none-1-ol

(Z)-5-phenylpent-4-en-1-ol

(E)-5-phenyl-4-penten-1-ol

5-phenyl-4-penten-1-ol