Ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate

Base Information

• Chemical Name: Ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate
• CAS No.: 19313-67-8
• Molecular Formula: C13H14O4
• Molecular Weight: 234.2479
• NSC Number: 85350
• DSSTox Substance ID: DTXSID70292758
• Nikkaji Number: J1.955.291H
• Mol file: 19313-67-8.mol

Synonyms:ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate;19313-67-8;NSC85350;NCIOpen2_004808;SCHEMBL8763832;DTXSID70292758;NSC-85350

Chemical Property of Ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate

Chemical Property:

• Vapor Pressure: 3.77E-06mmHg at 25°C
• Boiling Point: 385.6°Cat760mmHg
• Flash Point: 196.7°C
• Density: 1.213g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 234.08920892
• Heavy Atom Count: 17
• Complexity: 307

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1(CCOC1=O)C2=CC=CC=C2

Technology Process of Ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate

There total 2 articles about Ethyl 2-oxo-3-phenyltetrahydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium diethyl-2-phenylmalonate (28744-77-6) + ethylene dibromide (106-93-4) → carbethoxy-2 phenyl-2 γ-butyrolactone (19313-67-8)

Guidance literature:

With toluene; Erhitzen des Reaktionsprodukts unter vermindertem Druck;

DOI:10.1021/ja01281a029 DOI:10.1021/ja01145a143

Reference yield:

→ carbethoxy-2 phenyl-2 γ-butyrolactone (19313-67-8)

Guidance literature:

DOI:10.1007/BF00766097

Reference yield: 100.0%

carbethoxy-2 phenyl-2 γ-butyrolactone (19313-67-8) → 3-phenyldihydrofuran-2-one (6836-98-2)

Guidance literature:

With sodium hydroxide; at 80 ℃; for 2h;

upstream raw materials:

sodium diethyl-2-phenylmalonate

ethylene dibromide

Downstream raw materials:

3-phenyldihydrofuran-2-one