2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)-
CAS No.:874660-44-3
Molecular Formula:C41H63NO8Si
Molecular Weight:726.039
Hs Code.:

2-Oxazolidinone,
3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1-
methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop
yl]-4-(1-methylethyl)-, (4S)-

Synonyms:

Suppliers and Price of 2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)-

Chemical Property:

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Technology Process of 2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)-

There total 12 articles about 2-Oxazolidinone, 3-[(2R)-2-[[(1S,2R)-2-[(4-methoxyphenyl)methoxy]-1-methyl-1-[2-[[tris(1- methylethyl)silyl]oxy]ethyl]-4-pentenyl]oxy]-1-oxo-3-(phenylmethoxy)prop yl]-4-(1-methylethyl)-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 874660-21-6
(S)-4-Isopropyl-3-{2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

: 2749-70-4
bis(benzyloxy)methane

: 874660-44-3
(S)-3-{(R)-3-Benzyloxy-2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-propionyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: (S)-4-Isopropyl-3-{2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

bis(benzyloxy)methane; With trimethylsilyl iodide; In tetrahydrofuran; toluene; at -78 ℃;
DOI:10.1002/chem.200900776

Reference yield:

: 874660-21-6
(S)-4-Isopropyl-3-{2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

: 17482-09-6
benzyl iodomethyl ether

: 874660-44-3
(S)-3-{(R)-3-Benzyloxy-2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-propionyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: (S)-4-Isopropyl-3-{2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one; With sodium bis(trimethylsilyl)amide; In tetrahydrofuran; toluene; at -78 - -65 ℃;

benzyl iodomethyl ether; In tetrahydrofuran; toluene; for 0.25h;
DOI:10.1021/ol0526625

Reference yield:

: 874660-41-0
(R)-4-(4-Methoxy-benzyloxy)-hept-6-ene-1,3-diol

: 874660-44-3
(S)-3-{(R)-3-Benzyloxy-2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-propionyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

2.1: 96 percent / pyridine; Dess-Martin periodinane / CH₂Cl₂ / 1 h

3.1: 95 percent / tetrahydrofuran; diethyl ether / -78 °C

4.1: 73 percent / sodium hydride / tetrahydrofuran; dimethylformamide / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / -78 - 0 °C

6.1: n-butyl lithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

6.2: 40 g / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

7.1: sodium (trimethylsilyl)amide / tetrahydrofuran; toluene / -78 - -65 °C

7.2: tetrahydrofuran; toluene / 0.25 h

With pyridine; 1H-imidazole; n-butyllithium; sodium bis(trimethylsilyl)amide; sodium hydride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0526625