2-Propenoic acid, 3-[4-[[(1-aminocyclobutyl)carbonyl]amino]-2-ethoxyphenyl]-, methyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[4-[[(1-aminocyclobutyl)carbonyl]amino]-2-ethoxyphenyl]-, methyl ester, (2E)-
CAS No.:874676-76-3
Molecular Formula:C17H22N2O4
Molecular Weight:318.373
Hs Code.:

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[4-[[(1-aminocyclobutyl)carbonyl]amino]-2-ethoxyphenyl]-, methyl ester, (2E)-

Chemical Property:

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Technology Process of 2-Propenoic acid, 3-[4-[[(1-aminocyclobutyl)carbonyl]amino]-2-ethoxyphenyl]-, methyl ester, (2E)-

There total 5 articles about 2-Propenoic acid, 3-[4-[[(1-aminocyclobutyl)carbonyl]amino]-2-ethoxyphenyl]-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2486-66-0
2-ethoxy-4-nitrobenzoic acid

: 874676-76-3
(E)-3-{4-[(1-aminocyclobutanecarbonyl)amino]-2-ethoxyphenyl}acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / water; tetrahydrofuran / 5.42 h / 0 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / chloroform / 2.5 h / Reflux; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: iron; ammonium chloride / water; ethanol / 1 h / 85 °C / Inert atmosphere

5.1: acetonitrile / 20 h / 20 °C / Inert atmosphere

5.2: 0.25 h / Inert atmosphere

With manganese(IV) oxide; dimethylsulfide borane complex; iron; sodium hydride; ammonium chloride; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile; 3.2: |Wittig-Horner Reaction;
DOI:10.1021/jm501532z

Reference yield:

: 4-amino-2-ethoxycinnamic acid methyl ester

: 735287-43-1
1-amino-cyclobutanecarbonyl chloride hydrochloride

: 874676-76-3
(E)-3-{4-[(1-aminocyclobutanecarbonyl)amino]-2-ethoxyphenyl}acrylic acid methyl ester

Guidance literature:: 4-amino-2-ethoxycinnamic acid methyl ester; 1-amino-cyclobutanecarbonyl chloride hydrochloride; In acetonitrile; at 20 ℃; for 20h;

With potassium phosphate; In acetonitrile; at 20 ℃; for 0.25h;

Reference yield:

: 10473-47-9
2-Ethoxy-4-nitro-benzylalkohol

: 874676-76-3
(E)-3-{4-[(1-aminocyclobutanecarbonyl)amino]-2-ethoxyphenyl}acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / chloroform / 2.5 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

3.1: iron; ammonium chloride / water; ethanol / 1 h / 85 °C / Inert atmosphere

4.1: acetonitrile / 20 h / 20 °C / Inert atmosphere

4.2: 0.25 h / Inert atmosphere

With manganese(IV) oxide; iron; sodium hydride; ammonium chloride; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile; 2.2: |Wittig-Horner Reaction;
DOI:10.1021/jm501532z