Technology Process of 1-Azetidineacetic acid,3-[[(2Z)-[4-[(3S)-3- amino-3-carboxypropoxy]phenyl](hydroxyimino)- acetyl]amino]-R-(4-hydroxyphenyl)-2-oxo-,(RR,3S)-
There total 11 articles about 1-Azetidineacetic acid,3-[[(2Z)-[4-[(3S)-3- amino-3-carboxypropoxy]phenyl](hydroxyimino)- acetyl]amino]-R-(4-hydroxyphenyl)-2-oxo-,(RR,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: MeOH/H2O, reflux, 3 d
2: pyridine / 7 °C
3: 1.) NaN3; 2.) N2O4, NaOAc / 1.) DMSO, 50 degC, overnight, 2.) CHCl3, O degC, 1 h, room temp., 2 h
4: DBU / CH2Cl2 / 0.02 h / Ambient temperature
5: 100 percent / H2, NaHCO3 / Pd-C / H2O; ethyl acetate / 1 h
7: hydroxylamine hydrochloride, NaHCO3 / H2O / 2 h / 50 °C / pH 7
With
sodium azide; hydroxylamine hydrochloride; hydrogen; sodium acetate; dinitrogen tetraoxide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)92152-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine / 7 °C
2: 1.) NaN3; 2.) N2O4, NaOAc / 1.) DMSO, 50 degC, overnight, 2.) CHCl3, O degC, 1 h, room temp., 2 h
3: DBU / CH2Cl2 / 0.02 h / Ambient temperature
4: 100 percent / H2, NaHCO3 / Pd-C / H2O; ethyl acetate / 1 h
6: hydroxylamine hydrochloride, NaHCO3 / H2O / 2 h / 50 °C / pH 7
With
sodium azide; hydroxylamine hydrochloride; hydrogen; sodium acetate; dinitrogen tetraoxide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)92152-0
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodiumazide, 2.) N2O4 / 1.) DMSO, 5 h, 50 degC; 2.) CHCl3, 0 degC, NaOAc, 90 min
2: DBU / CH2Cl2 / 0.02 h / Ambient temperature
3: 100 percent / H2, NaHCO3 / Pd-C / H2O; ethyl acetate / 1 h
5: hydroxylamine hydrochloride, NaHCO3 / H2O / 2 h / 50 °C / pH 7
With
sodium azide; hydroxylamine hydrochloride; hydrogen; dinitrogen tetraoxide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)92152-0
