Technology Process of Methanone,
[6-[3-(1H-indol-6-yloxy)propoxy]-5-propyl-2-naphthalenyl]phenyl-
There total 5 articles about Methanone,
[6-[3-(1H-indol-6-yloxy)propoxy]-5-propyl-2-naphthalenyl]phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation
2: 97 percent / H2 / Pd/C / ethyl acetate / 2 h / 2280 Torr
3: K2CO3; KI / dimethylformamide / 110 °C
With
hydrogen; potassium carbonate; potassium iodide;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
1: Claisen rearrangement;
DOI:10.1021/jm0510373
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / H2 / Pd/C / ethyl acetate / 2 h / 2280 Torr
2: K2CO3; KI / dimethylformamide / 110 °C
With
hydrogen; potassium carbonate; potassium iodide;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0510373
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: KOH / dimethylsulfoxide / 0.5 h / 20 °C
1.2: 80 percent / dimethylsulfoxide / 2 h / 20 °C
2.1: 95 percent / 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation
3.1: 97 percent / H2 / Pd/C / ethyl acetate / 2 h / 2280 Torr
4.1: K2CO3; KI / dimethylformamide / 110 °C
With
potassium hydroxide; hydrogen; potassium carbonate; potassium iodide;
palladium on activated charcoal;
In
dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
2.1: Claisen rearrangement;
DOI:10.1021/jm0510373
