2-Azetidinone, 1-(4-methoxyphenyl)-3-methyl-3-(phenylthio)-

Base Information

Chemical Name:2-Azetidinone, 1-(4-methoxyphenyl)-3-methyl-3-(phenylthio)-
CAS No.:87568-30-7
Molecular Formula:C17H17NO2S
Molecular Weight:299.38700
Hs Code.:

Synonyms:2-Azetidinone,1-(4-methoxyphenyl)-3-methyl-3-(phenylthio);1-(p-methoxyphenyl)-3-methyl-3-(phenylthio)azetidin-2-one;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Azetidinone, 1-(4-methoxyphenyl)-3-methyl-3-(phenylthio)-

Chemical Property:

Boiling Point:528.7±45.0 °C(Predicted)
PSA：54.84000
Density:1.26±0.1 g/cm3(Predicted)
LogP:3.65780

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Azetidinone, 1-(4-methoxyphenyl)-3-methyl-3-(phenylthio)-

There total 1 articles about 2-Azetidinone, 1-(4-methoxyphenyl)-3-methyl-3-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7274-71-7
N-(4-methoxyphenyl)-2-methylacrylamide

: 931-59-9
benzenesulfenyl chloride

: 87568-30-7
1-(p-methoxyphenyl)-3-methyl-3-(phenylthio)azetidin-2-one

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; water; Yield given. Multistep reaction; 2.) C₆H₆, room temperature, 24 h;
DOI:10.1021/ja00363a023

Reference yield:

: 87568-30-7
1-(p-methoxyphenyl)-3-methyl-3-(phenylthio)azetidin-2-one

: 87568-46-5
3-(((benzyloxy)carbonyl)amino)-1-(p-methoxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / MCPBA / CH₂Cl₂ / 0.33 h / -78 °C

2: 78 percent / toluene / 20 h / Heating

3: 1.) O₃, 2.) Me₂S / 1.) AcOEt, -78 deg C, 15 min, 2.) -78 deg C, 20 min

4: 61 percent / H₂NOH*HCl, pyridine / methanol / 12 h / Ambient temperature

5: 75 percent / H₂ / 5percent rhodium-alumina / methanol / 4180 Torr / Ambient temperature

6: 88 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; dimethylsulfide; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; ozone; 3-chloro-benzenecarboperoxoic acid; rhodium on alumina; In methanol; dichloromethane; toluene;
DOI:10.1021/ja00363a023

Reference yield:

: 87568-30-7
1-(p-methoxyphenyl)-3-methyl-3-(phenylthio)azetidin-2-one

: 87568-45-4
3-amino-1-(p-methoxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / MCPBA / CH₂Cl₂ / 0.33 h / -78 °C

2: 78 percent / toluene / 20 h / Heating

3: 1.) O₃, 2.) Me₂S / 1.) AcOEt, -78 deg C, 15 min, 2.) -78 deg C, 20 min

4: 61 percent / H₂NOH*HCl, pyridine / methanol / 12 h / Ambient temperature

5: 75 percent / H₂ / 5percent rhodium-alumina / methanol / 4180 Torr / Ambient temperature

With pyridine; dimethylsulfide; hydroxylamine hydrochloride; hydrogen; ozone; 3-chloro-benzenecarboperoxoic acid; rhodium on alumina; In methanol; dichloromethane; toluene;
DOI:10.1021/ja00363a023