Carbamic acid, [3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[ 5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[ 5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester
CAS No.:876191-28-5
Molecular Formula:C24H32FN5O3S
Molecular Weight:489.614
Hs Code.:

Carbamic acid,
[3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[
5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[ 5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[ 5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[ 5,4-d]pyrimidin-6-yl]propyl]amino]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876191-27-4
6-(1-bromopropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one

: 75178-96-0
N-Boc-1,3-diaminopropane

: 876191-28-5
tert-butyl N-[3-[1-[5-[(3-fluorophenyl)methyl]-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl]propylamino]propyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 0.5h;

Reference yield:

: 162702-06-9
N-(4-cyano-3-methyl-1,2-thiazol-5-yl)butanamide

: 876191-28-5
tert-butyl N-[3-[1-[5-[(3-fluorophenyl)methyl]-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl]propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide; dihydrogen peroxide / water / 16 h / 60 °C

2: ammonium hydroxide / water / 4 h / 140 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

4: bromine; sodium acetate; acetic acid / 0.33 h / 100 °C

5: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / Reflux

With ammonium hydroxide; dihydrogen peroxide; bromine; sodium acetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200629m

Reference yield:

: 162702-38-7
5-(butanoylamino)-3-methyl-1,2-thiazole-4-carboxamide

: 876191-28-5
tert-butyl N-[3-[1-[5-[(3-fluorophenyl)methyl]-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl]propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / water / 4 h / 140 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

3: bromine; sodium acetate; acetic acid / 0.33 h / 100 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / Reflux

With ammonium hydroxide; bromine; sodium acetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200629m