Technology Process of Benzo[g]quinoline,
1,2,3,4,4a,5,10,10a-octahydro-6,8-dimethoxy-1-(phenylmethyl)-, trans-
There total 12 articles about Benzo[g]quinoline,
1,2,3,4,4a,5,10,10a-octahydro-6,8-dimethoxy-1-(phenylmethyl)-, trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.) NaH / 1.) toluene, reflux, 8 h, 2.) toluene, RT, 16 h
2: H2 / PtO2 / acetic acid / 2327.2 Torr
3: 100 percent / Et3N / CHCl3 / 3 h / Ambient temperature
4: 97 percent / KOH / ethanol / 5 h / Heating
5: 0.5 h / 175 - 180 °C
6: KOH / aq. ethanol / 4 h / Heating
7: 92 percent / H2 / 5percent Pd/C / acetic acid / 12 h / 2327.2 Torr
8: polyphosphoric acid / 1 h / 95 °C
9: AlCl3, LiAlH4 / tetrahydrofuran / 3.5 h / 60 °C
10: 5percent aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
11: LiAlH4 / tetrahydrofuran / 5 h / Heating
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; PPA; hydrogen; sodium hydride; triethylamine;
platinum(IV) oxide; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1021/jm00368a015
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.) NaH / 1.) toluene, reflux, 8 h, 2.) toluene, RT, 16 h
2: H2 / PtO2 / acetic acid / 2327.2 Torr
3: 100 percent / Et3N / CHCl3 / 3 h / Ambient temperature
4: 97 percent / KOH / ethanol / 5 h / Heating
5: 0.5 h / 175 - 180 °C
6: KOH / aq. ethanol / 4 h / Heating
7: 92 percent / H2 / 5percent Pd/C / acetic acid / 12 h / 2327.2 Torr
8: polyphosphoric acid / 1 h / 95 °C
9: AlCl3, LiAlH4 / tetrahydrofuran / 3.5 h / 60 °C
10: 5percent aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
11: LiAlH4 / tetrahydrofuran / 5 h / Heating
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; PPA; hydrogen; sodium hydride; triethylamine;
platinum(IV) oxide; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1021/jm00368a015
- Guidance literature:
-
Multi-step reaction with 10 steps
1: H2 / PtO2 / acetic acid / 2327.2 Torr
2: 100 percent / Et3N / CHCl3 / 3 h / Ambient temperature
3: 97 percent / KOH / ethanol / 5 h / Heating
4: 0.5 h / 175 - 180 °C
5: KOH / aq. ethanol / 4 h / Heating
6: 92 percent / H2 / 5percent Pd/C / acetic acid / 12 h / 2327.2 Torr
7: polyphosphoric acid / 1 h / 95 °C
8: AlCl3, LiAlH4 / tetrahydrofuran / 3.5 h / 60 °C
9: 5percent aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
10: LiAlH4 / tetrahydrofuran / 5 h / Heating
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; PPA; hydrogen; triethylamine;
platinum(IV) oxide; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1021/jm00368a015
