15601-07-7Relevant academic research and scientific papers
Asymmetric total synthesis of nigerone
DiVirgilio, Evan S.,Dugan, Elizabeth C.,Mulrooney, Carol A.,Kozlowski, Marisa C.
, p. 385 - 388 (2007)
An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative
Cereal grain resorcinolic lipids: mono and dienoic homologues are present in rye grains
Kozubek, Arkadiusz,Tyman, John H. P.
, p. 29 - 36 (1995)
Analyses (UV, IR, 1H-NMR, MS) of the main phenolic fraction isolated by sequential separation on normal-phase and argentation chromatography on silica gel confirmed the presence of monoenoic and dienoic homologues of 1,3-dihydroxy-5-n-alkylbenzene in acet
FGFR4 kinase inhibitor, preparation method and uses thereof
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Paragraph 0203-0204; 0208-0209, (2020/04/17)
The present invention relates to a compound represented by a formula (I), or a pharmaceutically acceptable salt, a solvate, a polymorph or an isomer thereof, and uses in preparation of drugs for treatment of FGFR4 mediated diseases.
The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols
He, Zhen,Pulis, Alexander P.,Procter, David J.
supporting information, p. 7813 - 7817 (2019/05/15)
A benzothiophene S-oxide catalyst, generated in situ by sulfur oxidation with H2O2, mediates the oxidative coupling of 2-naphthols. Key to the catalytic process is the capture and inversion of reactivity of a 2-naphthol partner, using an interrupted Pummerer reaction of an unusual benzothiophene S-oxide, followed by subsequent coupling with a second partner. The new catalytic manifold has been showcased in the synthesis of the bioactive natural products, (±)-nigerone and (±)-isonigerone. Although Pummerer reactions are used widely, their application in catalysis is rare, and our approach represents a new catalytic manifold for metal-free C?C bond formation.
Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)3·9H2O
Thurow, Samuel,Fernandes, Alessandra A. G.,Quevedo-Acosta, Yovanny,De Oliveira, Matheus F.,De Oliveira, Marcelo G.,Jurberg, Igor D.
supporting information, p. 6909 - 6913 (2019/09/12)
A thermal protocol is reported for the formal insertion of nitric acid into aryldiazoacetates using Fe(NO3)3·9H2O. This strategy is mild and high yielding and allows the preparation of a large variety of members of an unprecedented family of organic nitrates. The nitrate group can be also readily transformed into other functional groups and heterocyclic moieties and can possibly allow new biological explorations of untapped potential associated with their NO-releasing ability.
Fibroblast growth factor receptor selective inhibitor and application thereof
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Paragraph 0155; 0156; 0157, (2017/08/02)
The invention relates to a fibroblast growth factor receptor selective inhibitor and application thereof. The invention provides a compound of a formula (I), a three-dimensional isomer, a tautomer or a pharmaceutically acceptable salt thereof, and an appl
Fibroblast growth factor receptor selective inhibitor and applications thereof
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Paragraph 0162-0165, (2017/08/23)
The invention discloses a fibroblast growth factor receptor selective inhibitor and applications thereof. The invention provides a compound as shown in a formula (I), and a stereoisomer, a tautomer or pharmaceutically accepted salts thereof, and applicati
Convenient syntheses of 3-aryl-3,4-dihydroisocoumarins
Limaye, Rohan A.,Joseph, Augustine R.,Natu, Arun D.,Paradkar, Madhusudan V.
, p. 191 - 194 (2015/06/02)
A convenient method for the synthesis of naturally occurring 3,4-dihydroisocoumarins by judicious use of Friedel-Craft acylation, regioselective formylation and oxidative cyclisation reactions is described. O-methylated analogues of montroumarin and thunb
Controlled-deactivation cannabinergic ligands
Sharma, Rishi,Nikas, Spyros P.,Paronis, Carol A.,Wood, Jodianne T.,Halikhedkar, Aneetha,Guo, Jason Jianxin,Thakur, Ganesh A.,Kulkarni, Shashank,Benchama, Othman,Raghav, Jimit Girish,Gifford, Roger S.,J?rbe, Torbj?rn U. C.,Bergman, Jack,Makriyannis, Alexandros
, p. 10142 - 10157 (2014/01/17)
We report an approach for obtaining novel cannabinoid analogues with controllable deactivation and improved druggability. Our design involves the incorporation of a metabolically labile ester group at the 2′-position on a series of (-)-Δ8-THC a
Biomimetic asymmetric synthesis of (R)-GTRI-02 and (3 S,4 R)-3,4-dihydroxy-3,4-dihydronaphthalen-1(2H)-ones
Husain, Syed Masood,Schaetzle, Michael A.,Roehr, Caroline,Luedeke, Steffen,Mueller, Michael
supporting information; experimental part, p. 3600 - 3603 (2012/09/07)
The NADPH-dependent tetrahydroxynaphthalene reductase (T4HNR) from Magnaporthe grisea was used for the biomimetic synthesis of (R)-GTRI-02 by stereoselective reduction of 1-(3,6,8-trihydroxy-1-methylnaphthalen-2-yl) ethanone. This also led to t
