17216-62-5Relevant articles and documents
Intramolecular Schmidt reaction of acyl chlorides with alkyl azides: Preparation of pyrrolizine by intramolecular capture of intermediates with alkenes or alkynes
Wang, Bao-Juan,Xue, Ping,Gu, Peiming
, p. 2277 - 2279 (2015)
The preparation of substituted pyrrolizines through the Schmidt reaction of acyl chlorides with alkyl azides has been realized. Intramolecular capture of the isocyanate ion and N-acyliminium ion intermediates from the Schmidt process with alkene or alkyne
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Wessely et al.
, p. 678,687 (1952)
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DIASTEREOMERIC LINKING REAGENTS FOR NUCLEOTIDE PROBES
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Paragraph 94-97, (2021/04/02)
A versatile reagent with a non-nucleotide monomeric unit comprising an enantiomeric center and having a ligand, and first and second coupling groups that are linked to the non-nucleotide monomeric unit. Such a reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can, for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.
2 - Oxygen -3 - piperidine carboxylic acid ethyl ester preparation method (by machine translation)
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Paragraph 0025; 0026; 0029; 0030; 0031, (2018/09/21)
The invention provides a 2 - oxo - 3 - piperidine carboxylic acid ethyl ester preparation method, comprising the following steps: S1, the malonic acid diethyl ester and alkaline catalyst after mixing, in the 10 - 50 °C dropping acrylonitrile, obtained by reaction of 2 - cyanoethyl malonic acid diethyl ester; S2, will be the 2 - cyanoethyl malonic acid diethyl ester and organic solvent, [...] catalyst in the hydrogen environment, for 75 - 130 °C react under the, recrystallization to obtain the 2 - oxo - 3 - piperidine carboxylic acid ethyl ester. Compared with the prior art, this invention has the following advantages: the present invention provides a 2 - oxo - 3 - piperidine ethyl formate manufacturing method, with raw materials are easy, simple operation, total yield compared with the classic N·F·Albertsm method up to 77% above (improved 20%), so it is very suitable for industrial production. (by machine translation)