1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl-

Base Information

• Chemical Name: 1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl-
• CAS No.: 87831-10-5
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• DSSTox Substance ID: DTXSID60440064
• Nikkaji Number: J2.350.927J

Synonyms:1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl-;87831-10-5;DTXSID60440064;beta-Hydroxy-beta-(2-methoxyphenyl)propiophenone

Chemical Property of 1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl-

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.109944368
• Heavy Atom Count: 19
• Complexity: 284

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(CC(=O)C2=CC=CC=C2)O

Technology Process of 1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl-

There total 12 articles about 1-Propanone, 3-hydroxy-3-(2-methoxyphenyl)-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-styrenyloxytrimethylsilane (13735-81-4) + ortho-anisaldehyde (135-02-4) → 3-hydroxy-3-(2-methoxy-phenyl)-1-phenyl-propan-1-one (87831-10-5)

Guidance literature:

1-styrenyloxytrimethylsilane; ortho-anisaldehyde; With C₄₀H₆₁Al₃O₃; In acetonitrile; at 20 ℃; for 3h;

With hydrogenchloride; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1080/10426507.2014.906427

Reference yield: 91.0%

2,3-epoxy-3-(2-metoxyphenyl)-1-phenylpropan-1-one (68235-45-0) → 3-hydroxy-3-(2-methoxy-phenyl)-1-phenyl-propan-1-one (87831-10-5)

Guidance literature:

With sodium dithionite; sodium carbonate; 3-(aminocarbonyl)-1-benzylpyridinium bromide; In water; ethyl acetate; at 20 ℃;

DOI:10.1021/ol0610892

Reference yield: 85.0%

(R)-4-(2-Oxo-2-phenyl-ethyl)-1-propyl-1,4-dihydro-pyridine-3-carboxylic acid phenylamide + ortho-anisaldehyde (135-02-4) → 3-hydroxy-3-(2-methoxy-phenyl)-1-phenyl-propan-1-one (87831-10-5)

Guidance literature:

With magnesium(II) perchlorate; In acetone; at 20 ℃; for 1h;

DOI:10.1021/ja00364a079

upstream raw materials:

ortho-anisaldehyde

(4S,14S)-4,14-Diisopropyl-19-methyl-21-(2-oxo-2-phenyl-ethyl)-6,9,12-trioxa-3,15,19-triaza-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17-diene-2,5,13,16-tetraone

α-bromoacetophenone

2,3-epoxy-3-(2-metoxyphenyl)-1-phenylpropan-1-one

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