5-Heptenoic acid, 7-[(1R,2S,5S)-2-hydroxy-5-[4-[1-(phenylmethoxy)hexyl]phenyl]cyclopent yl]-, (5Z)-

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Chemical Name:5-Heptenoic acid, 7-[(1R,2S,5S)-2-hydroxy-5-[4-[1-(phenylmethoxy)hexyl]phenyl]cyclopent yl]-, (5Z)-
CAS No.:879098-70-1
Molecular Formula:C31H42O4
Molecular Weight:478.672
Hs Code.:

Synonyms:

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Chemical Property of 5-Heptenoic acid, 7-[(1R,2S,5S)-2-hydroxy-5-[4-[1-(phenylmethoxy)hexyl]phenyl]cyclopent yl]-, (5Z)-

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Technology Process of 5-Heptenoic acid, 7-[(1R,2S,5S)-2-hydroxy-5-[4-[1-(phenylmethoxy)hexyl]phenyl]cyclopent yl]-, (5Z)-

There total 7 articles about 5-Heptenoic acid, 7-[(1R,2S,5S)-2-hydroxy-5-[4-[1-(phenylmethoxy)hexyl]phenyl]cyclopent yl]-, (5Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879098-65-4
Acetic acid (1R,4S)-4-(1-butoxy-2-iodo-ethoxy)-cyclopent-2-enyl ester

: 879098-70-1
(Z)-7-{(1R,2S,5S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: CoCl₂; (R,R)-1,2-bis(dimethylamino)cyclohexane / tetrahydrofuran / 0.25 h / 25 °C

1.2: 54 percent / Jones reagent / acetone / 20 °C

2.1: 85 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

3.1: pyridine; N,N-dimethyl-4-aminopyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 235 mg / AIBN; (Me₃Si)3SiH / toluene / 1 h / Heating

5.1: 84 percent / DIBAL-H / toluene; hexane / 0.5 h / -60 °C

6.1: sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

6.2: 87 percent / tetrahydrofuran / 1 h / 20 °C

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; (1R,2R)-bis(dimethylamino)cyclohexane; sodium hexamethyldisilazane; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ja057560o

Reference yield:

: C₁₉H₂₃BrMgO

: 879098-70-1
(Z)-7-{(1R,2S,5S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: CoCl₂; (R,R)-1,2-bis(dimethylamino)cyclohexane / tetrahydrofuran / 0.25 h / 25 °C

1.2: 54 percent / Jones reagent / acetone / 20 °C

2.1: 85 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

3.1: pyridine; N,N-dimethyl-4-aminopyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 235 mg / AIBN; (Me₃Si)3SiH / toluene / 1 h / Heating

5.1: 84 percent / DIBAL-H / toluene; hexane / 0.5 h / -60 °C

6.1: sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

6.2: 87 percent / tetrahydrofuran / 1 h / 20 °C

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; (1R,2R)-bis(dimethylamino)cyclohexane; sodium hexamethyldisilazane; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ja057560o

Reference yield:

: 879098-69-8
(3aR,4S,6aS)-4-[4-(1-Benzyloxy-hexyl)-phenyl]-hexahydro-cyclopenta[b]furan-2-one

: 879098-70-1
(Z)-7-{(1R,2S,5S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / DIBAL-H / toluene; hexane / 0.5 h / -60 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

2.2: 87 percent / tetrahydrofuran / 1 h / 20 °C

With sodium hexamethyldisilazane; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ja057560o