Benzyl benzyl(cyclopropyl)carbamate

Base Information

• Chemical Name: Benzyl benzyl(cyclopropyl)carbamate
• CAS No.: 88048-45-7
• Molecular Formula: C18H19NO2
• Molecular Weight: 281.354
• DSSTox Substance ID: DTXSID50521270
• Wikidata: Q82385656
• Mol file: 88048-45-7.mol

Synonyms:Benzyl benzyl(cyclopropyl)carbamate;88048-45-7;DTXSID50521270

Chemical Property of Benzyl benzyl(cyclopropyl)carbamate

Chemical Property:

• PSA: 29.54000
• LogP: 3.98780
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 281.141578849
• Heavy Atom Count: 21
• Complexity: 328

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1N(CC2=CC=CC=C2)C(=O)OCC3=CC=CC=C3

Technology Process of Benzyl benzyl(cyclopropyl)carbamate

There total 2 articles about Benzyl benzyl(cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-carbobenzyloxy-N-benzylcyclopropylamine (88048-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / toluene; H₂O / 5 - 21 °C

2: 1) NaH / 1) DMF

With sodium hydride; sodium carbonate; In water; toluene;

DOI:10.1002/jhet.5570200438

Reference yield:

benzyl bromide (100-39-0) + N-carbobenzyloxycyclopropylamine (88048-43-5) → N-carbobenzyloxy-N-benzylcyclopropylamine (88048-45-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMF;

DOI:10.1002/jhet.5570200438

Reference yield: 77.0%

N-carbobenzyloxy-N-benzylcyclopropylamine (88048-45-7) → N-benzylcyclopropanamine (13324-66-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 760 Torr;

DOI:10.1002/jhet.5570200438

upstream raw materials:

benzyl bromide

N-carbobenzyloxycyclopropylamine

benzyl chloroformate

Downstream raw materials:

N-benzylcyclopropanamine

N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide