Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate

Base Information

Chemical Name:Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate
CAS No.:88072-21-3
Molecular Formula:C12H13NO3
Molecular Weight:219.24
Hs Code.:
DSSTox Substance ID:DTXSID70539458
Wikidata:Q82415219

Synonyms:Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate;88072-21-3;DTXSID70539458

Suppliers and Price of Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:219.08954328
Heavy Atom Count:16
Complexity:303

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)C(=O)OC)N2CCC2=O

Technology Process of Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate

There total 3 articles about Methyl 3-methyl-4-(2-oxoazetidin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 88072-10-0
4-(3-Bromo-propionylamino)-3-methyl-benzoic acid methyl ester

: 88072-21-3
3-Methyl-4-(2-oxo-azetidin-1-yl)-benzoic acid methyl ester

Guidance literature:: With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 24078-21-5
methyl 3-methyl-4-nitrobenzoate

: 88072-21-3
3-Methyl-4-(2-oxo-azetidin-1-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / PtO₂, 80percent / methanol / 20 h / 25 °C / 735.5 Torr

2: 49 percent / 2,6-lutidine / benzene

3: 35 percent / NaH / dimethylformamide; CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; sodium hydride; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

: 18595-14-7
methyl 4-amino-3-methylbenzoate

: 88072-21-3
3-Methyl-4-(2-oxo-azetidin-1-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / 2,6-lutidine / benzene

2: 35 percent / NaH / dimethylformamide; CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; benzene;