Ethyl DL-leucinate hydrochloride

Base Information

• Chemical Name: Ethyl DL-leucinate hydrochloride
• CAS No.: 2743-40-0
• Molecular Formula: C8H18ClNO2
• Molecular Weight: 195.689
• Hs Code.: 29224999
• European Community (EC) Number: 245-650-8
• NSC Number: 401319,45692
• Mol file: 2743-40-0.mol

Synonyms:Ethyl DL-leucinate hydrochloride;23420-04-4;Ethyl DL-leucinate HCl;ethyl 2-amino-4-methylpentanoate hydrochloride;ethyl 2-amino-4-methylpentanoate;hydrochloride;EINECS 245-650-8;leucine ethyl ester hydrochloride;ethyl (2S)-2-amino-4-methylpentanoate;starbld0023259;SCHEMBL818970;NOUDPBCEONUCOV-UHFFFAOYSA-N;dl-leucine ethyl ester hydrochloride;NSC45692;NSC-45692;NSC401319;AKOS022902435;NSC-401319;Leucine, ethyl ester, hydrochloride, DL-;FT-0627934;FT-0653603;FT-0655711;A819063;A837960;(2S)-2-amino-4-methylpentanoic acid ethyl ester hydrochloride

Chemical Property of Ethyl DL-leucinate hydrochloride

Chemical Property:

• Appearance/Colour: crystalline
• Vapor Pressure: 0.515mmHg at 25°C
• Melting Point: 134-136 °C
• Refractive Index: 19 ° (C=5, EtOH)
• Boiling Point: 191.4 °C at 760 mmHg
• Flash Point: 62.9 °C
• PSA: 52.32000
• Density: 0.944g/cm3
• LogP: 2.42520
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 195.1026065
• Heavy Atom Count: 12
• Complexity: 123

Purity/Quality:

99% ^*data from raw suppliers

L-Leucine ethyl ester HCl ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)C(CC(C)C)N.Cl
• Uses: L-Leucine ethyl ester hydrochloride is used as an organic chemical synthesis intermediate.

Technology Process of Ethyl DL-leucinate hydrochloride

There total 6 articles about Ethyl DL-leucinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

PChd-LeuLOEt (82636-80-4) → 2,6-di(t-butyl)-4-phenylphenol (2668-47-5) + DL-leucine ethyl ester hydrochloride (2743-40-0,23420-04-4,73913-65-2)

Guidance literature:

With hydrogenchloride; In methanol; electrolysis;

DOI:10.1016/S0040-4039(01)80091-5

Reference yield: 80.0%

ethanol (64-17-5) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → L-leucine ethyl ester hydrochloride (2743-40-0)

Guidance literature:

With thionyl chloride; at 0 ℃; for 8h; Schlenk technique; Reflux;

DOI:10.1039/c7ra00073a

Reference yield:

ethanol (64-17-5) + LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → DL-leucine ethyl ester hydrochloride (2743-40-0,23420-04-4,73913-65-2)

Guidance literature:

With thionyl chloride; for 12h;

DOI:10.1002/anie.200603745

upstream raw materials:

ethanol

L-leucine

N-Boc-L-leucine ethyl ester

PChd-LeuLOEt

Downstream raw materials:

N-carbonyl-L-leucine ethyl ester

Benzyloxycarbonyl-L-glutaminyl-L-leucin-aethylester

BOC-ε-Z-Lys-Leu-OEt

N-(o-carboxybenzoyl)-L-leucine