Benzenecarbodithioic acid, 2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl ester

Base Information

• Chemical Name: Benzenecarbodithioic acid, 2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl ester
• CAS No.: 881212-56-2
• Molecular Formula: C14H13NO4S2
• Molecular Weight: 323.394
• Mol file: 881212-56-2.mol

Synonyms:

Chemical Property of Benzenecarbodithioic acid, 2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarbodithioic acid, 2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl ester

There total 2 articles about Benzenecarbodithioic acid, 2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-((phenylcarbonothioyl)thio)propanoic acid (78751-36-7) → succinimido-2-[[2-phenyl-1-thioxo]thio]-propanoate (881212-56-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 23h;

DOI:10.1021/ja057481c

Reference yield:

phenylmagnesium bromide → succinimido-2-[[2-phenyl-1-thioxo]thio]-propanoate (881212-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / tetrahydrofuran

2: N,N'-dicyclohexylcarbodiimide / CHCl₃ / 23 h / 0 - 20 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;

DOI:10.1021/ja057481c

Reference yield: 72.0%

succinimido-2-[[2-phenyl-1-thioxo]thio]-propanoate (881212-56-2) + N-(8-amino-3,6-dioxaoctanyl)biotinamide (138529-46-1) → N-[8-((+)-biotinamido)-3,6-dioxaoctyl]-2-[[2-phenyl-1-thioxo]thio]propanamide (881212-59-5)

Guidance literature:

In chloroform; at 30 ℃; for 2h;

DOI:10.1021/ja057481c

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-((phenylcarbonothioyl)thio)propanoic acid

Downstream raw materials:

N-(2-morpholinoethyl)-2-[[2-phenyl-1-thioxo]thio]-propanamide

N-[6-desoxy-1,2:3,4-di-O-isopropylinene-6-α-D-galactopyranosyl]-2-[[2-phenyl-1-thioxo]thio]-propanamide

N-[8-((+)-biotinamido)-3,6-dioxaoctyl]-2-[[2-phenyl-1-thioxo]thio]propanamide

N-[4-(9-phenanthrenyl)butyl-2-(2-phenyl-1-thioxo)thio]-propanamide