78751-36-7Relevant academic research and scientific papers
Molecular weight and functional end group control by RAFT polymerization of a bisubstituted acrylamide derivative
D'Agosto, Franck,Hughes, Robert,Charreyre, Marie-Therese,Pichot, Christian,Gilbert, Robert G.
, p. 621 - 629 (2003)
Controlled radical polymerization of the bisubstituted acrylamide derivative N-acryloyl-morpholine (NAM) has the potential to yield telechelic polymers, one end of which can subsequently be grafted to latex particles. Once grafted, the other chain end of the polymer can be used as an immobilization site for species with applications in molecular biology and biomedicine. The controlled polymerization of NAM using reversible addition-fragmentation chain transfer (RAFT) is performed using two new chain transfer agents S = C(Z)-SR bearing the same functional propanoic acid group (R) and two different Z groups, benzyl (CTA 1) and phenyl (CTA 2). RAFT polymerization of NAM mediated by CTA 1 is very fast (>80% conversion in less than half an hour at 65 °C). The linear evolution of Mn and the low polydispersity indices (Mw/Mn a living polymerization. CTA 2 leads to broader Mw/Mn's (1H NMR and MALDI-ToF mass spectrometry.
CONTINUOUS FLOW SYNTHESIS OF DITHIOESTER COMPOUNDS
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, (2014/10/04)
The present technology relates to methods of producing various dithioester-containing compounds via continuous flow reactors.
Versatile precursors of functional RAFT agents. Application to the synthesis of bio-related end-functionalized polymers
Bathfield, Mael,D'Agosto, Franck,Spitz, Roger,Charreyre, Marie-Therese,Delair, Thierry
, p. 2546 - 2547 (2007/10/03)
Biomolecule-polymer conjugates are widely used in bio-related fields, but their synthesis is often tricky, especially the introduction of a single biomolecule at one chain end. This paper describes a new straightforward approach to prepare such conjugates
Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents
Anderson,Jones
, p. 1559 - 1565 (2007/10/02)
A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.
