2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene

Base Information

Chemical Name:2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene
CAS No.:88149-87-5
Molecular Formula:C17H13FO2S2
Molecular Weight:332.419
Hs Code.:
DSSTox Substance ID:DTXSID50438374
Wikidata:Q82254099
Pharos Ligand ID:FBN6PVPJ19F9
ChEMBL ID:CHEMBL305060

Synonyms:2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene;CHEMBL305060;88149-87-5;SCHEMBL8985356;DTXSID50438374;DTVXNOVVMAMQNU-UHFFFAOYSA-N;BDBM50285227;2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene;2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-thiophene

Suppliers and Price of 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:332.03410016
Heavy Atom Count:22
Complexity:458

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)C1=CC=C(C=C1)C2=C(SC=C2)C3=CC=C(C=C3)F

Technology Process of 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene

There total 11 articles about 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 88149-83-1
2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene

: 88149-87-5
2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene

Guidance literature:: With Oxone; In methanol; water;
DOI:10.1016/S0960-894X(96)00513-6

Reference yield: 55.0%

: 88149-94-4
5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene

: 88149-87-5
2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene

: 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)thiophene

Guidance literature:: With copper(l) iodide; sodium 2,2,2-trifluoroacetate; In N,N-dimethyl acetamide; for 5h; Heating;
DOI:10.1248/cpb.46.279

Reference yield:

: 2-bromo-3-(4-iodophenyl)thiophene

: 88149-87-5
2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium L-prolinate; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Sealed tube; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 12 h / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; sodium L-prolinate; In 1,4-dioxane; water; dimethyl sulfoxide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1002/anie.202109026