2-Amino-1-(4-hydroxyphenyl)ethanone hydrochloride

Base Information

• Chemical Name: 2-Amino-1-(4-hydroxyphenyl)ethanone hydrochloride
• CAS No.: 19745-72-3
• Molecular Formula: C8H9 N O2 . Cl H
• Molecular Weight: 187.626
• Hs Code.: 2922509090
• European Community (EC) Number: 606-368-4
• DSSTox Substance ID: DTXSID40173429
• Mol file: 19745-72-3.mol

Synonyms:4-HAAC;4-hydroxy-alpha-aminoacetophenone

Chemical Property of 2-Amino-1-(4-hydroxyphenyl)ethanone hydrochloride

Chemical Property:

• Vapor Pressure: 2.02E-05mmHg at 25°C
• Melting Point: 249–251°C
• Boiling Point: 351.4°Cat760mmHg
• Flash Point: 166.3°C
• PSA: 63.32000
• Density: g/cm³
• LogP: 2.03590
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 187.0400063
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4''-hydroxyacetophenonehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)CN)O.Cl

Technology Process of 2-Amino-1-(4-hydroxyphenyl)ethanone hydrochloride

There total 4 articles about 2-Amino-1-(4-hydroxyphenyl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(4'-hydroxyphenyl)-1-ethanone (2491-38-5) → ω-amino-4-hydroxyacetophenone hydrochloride (19745-72-3)

Guidance literature:

2-bromo-1-(4'-hydroxyphenyl)-1-ethanone; With hexamethylenetetramine; In chloroform; at 20 ℃; for 1h;

With hydrogenchloride; In ethanol; at 20 ℃; for 1h; Further stages.;

DOI:10.1016/j.bmc.2007.11.048

Reference yield:

2-aminoacetonitrile hydrochloride (6011-14-9) + phenol (108-95-2,27073-41-2) → ω-amino-4-hydroxyacetophenone hydrochloride (19745-72-3)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

→ ω-amino-4-hydroxyacetophenone hydrochloride (19745-72-3)

Guidance literature:

With hydrogenchloride; at 160 - 170 ℃; im Rohr;

upstream raw materials:

2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

2-amino-1-(4-hydroxyphenyl)ethyl ketone

2-aminoacetonitrile hydrochloride

phenol

Downstream raw materials:

3,6-bis-(4-hydroxy-phenyl)-2,5-dihydro-pyrazine

2-ethoxycarbonylmethyl-4-(4-hydroxy-phenyl)-pyrrole-3-carboxylic acid ethyl ester

C₁₈H₁₈N₂O₅

C₂₈H₂₉N₃O₉

Refernces

• 1、 Nian, Siyun,Gan, Xia,Tan, Xiangduan,Yu, Zhenpeng,Wang, Panfeng,Chen, Xing,Wang, Guoping. "Discovery and synthesis of a novel series of liver X receptor antagonists". . p. 628 - 635. Retrieved 2015/09/07.
• 2、 Xue, Na,Yang, Xiaochun,Wu, Rui,Chen, Jing,He, Qiaojun,Yang, Bo,Lu, Xiuyang,Hu, Yongzhou. "Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents". . p. 2550 - 2557. Retrieved 2008/09/21.