Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-
CAS No.:88288-14-6
Molecular Formula:C9H7F4NO
Molecular Weight:221.15200
Hs Code.:
DSSTox Substance ID:DTXSID70449684
Wikidata:Q82269202
Mol file:88288-14-6.mol

Synonyms:Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-;88288-14-6;N-[2-fluoro-4-(trifluoromethyl)phenyl]acetamide;SCHEMBL9185909;DTXSID70449684;FUCRSTYWIKRQLA-UHFFFAOYSA-N

Suppliers and Price of Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
N-(2-Fluoro-4-trifluoromethyl-phenyl)-acetamide ＞95%
1 G
$ 150.00

Total 3 raw suppliers

Chemical Property of Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-

Chemical Property:

Melting Point:135-137 °C
Boiling Point:278.5±40.0 °C(Predicted)
PKA:13.32±0.70(Predicted)
PSA：32.59000
Density:1.380±0.06 g/cm3(Predicted)
LogP:3.45240
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:221.04637650
Heavy Atom Count:15
Complexity:241

Purity/Quality:: N-(2-Fluoro-4-trifluoromethyl-phenyl)-acetamide ＞95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C=C1)C(F)(F)F)F

Technology Process of Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]-

There total 2 articles about Acetamide, N-[2-fluoro-4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 349-97-3
4-(trifluromethyl)acetanilide

: 88288-14-6
2-fluoro-4-(trifluoromethyl)acetanilide

Guidance literature:: With acetyl hypofluorite; In dichloromethane; trichlorofluoromethane; at -75 ℃;
DOI:10.1021/jo00179a012

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 88288-14-6
2-fluoro-4-(trifluoromethyl)acetanilide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / CHCl₃ / 2 h / Ambient temperature

2: 8.7 g / fluoroxytrifluoromethane, AcOH / 8 h

With hypofluorous acid trifluoromethyl ester; acetic acid; In chloroform;
DOI:10.1021/jo00223a030