1-(5,6-Dichloro-1H-benzo[d]iMidazol-2-yl)ethanone

Base Information

• Chemical Name: 1-(5,6-Dichloro-1H-benzo[d]iMidazol-2-yl)ethanone
• CAS No.: 882977-63-1
• Molecular Formula: C₉H₆Cl₂N₂O
• Molecular Weight: 229.065
• Hs Code.: 2933990090
• Mol file: 882977-63-1.mol

Synonyms:

Chemical Property of 1-(5,6-Dichloro-1H-benzo[d]iMidazol-2-yl)ethanone

Chemical Property:

• Boiling Point: 415.3±48.0 °C(Predicted)
• PKA: 7.52±0.10(Predicted)
• PSA: 45.75000
• Density: 1.521±0.06 g/cm3(Predicted)
• LogP: 3.07230

Purity/Quality:

97% ^*data from raw suppliers

1-(5,6-Dichloro-1H-benzoimidazol-2-yl)-ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5,6-Dichloro-1H-benzo[d]iMidazol-2-yl)ethanone

There total 3 articles about 1-(5,6-Dichloro-1H-benzo[d]iMidazol-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-(5,6-dichlorobenzoimidazol-2-yl)ethanol (929079-82-3) → 1-(5,6-dichloro-1H-benzimidazol-2-yl)-ethanone (882977-63-1)

Guidance literature:

With potassium dichromate; sulfuric acid; In water; at 20 ℃; for 3.33333h;

DOI:10.1002/ejoc.201700733

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → 1-(5,6-dichloro-1H-benzimidazol-2-yl)-ethanone (882977-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / aq. HCl / 100 °C

2: K₂Cr₂O₇; aq. H₂SO₄

With hydrogenchloride; potassium dichromate; sulfuric acid;

DOI:10.1016/j.bmcl.2006.10.071

Reference yield:

4,5-dichloro-2-nitroaniline (6641-64-1) → 1-(5,6-dichloro-1H-benzimidazol-2-yl)-ethanone (882977-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / 30 °C

2: hydrogenchloride / water / 5 h / 90 °C

3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite / water; acetonitrile / 0.5 h

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium on activated charcoal; hydrogen; potassium bromide; In water; acetonitrile;

DOI:10.1039/c8ra10338k

upstream raw materials:

1-(5,6-dichlorobenzoimidazol-2-yl)ethanol

4,5-Dichloro-1,2-phenylenediamine

4,5-dichloro-2-nitroaniline

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