N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide

Base Information

Chemical Name:N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide
CAS No.:88303-16-6
Molecular Formula:C13H18FNO2S
Molecular Weight:271.356
Hs Code.:
DSSTox Substance ID:DTXSID70529612
Wikidata:Q82400154

Synonyms:88303-16-6;N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide;SCHEMBL11116465;DTXSID70529612

Suppliers and Price of N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:271.10422815
Heavy Atom Count:18
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N(C2CCCCC2)F

Technology Process of N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide

There total 4 articles about N-Cyclohexyl-N-fluoro-4-methylbenzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 80-30-8
N-cyclohexyl-p-toluenesulfonamide

: 88303-16-6
N-cyclohexyl-N-fluoro-4-methylbenzenesulfonamide

Guidance literature:: With fluorine; In chloroform; trichlorofluoromethane; at -78 ℃; for 4h;
DOI:10.1021/ja00314a050

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 88303-16-6
N-cyclohexyl-N-fluoro-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / Inert atmosphere

2.1: sodium hydride / dichloromethane / 1 h / 30 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/acs.orglett.1c01232

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 88303-16-6
N-cyclohexyl-N-fluoro-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / Inert atmosphere

2.1: sodium hydride / dichloromethane / 1 h / 30 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/acs.orglett.1c01232