3-Oxazolidinecarboxylic acid, 4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-
CAS No.:883443-06-9
Molecular Formula:C33H40F2N2O4
Molecular Weight:566.688
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy
propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-

Synonyms:

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-

There total 4 articles about 3-Oxazolidinecarboxylic acid, 4-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 883439-28-9
(R)-4-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 100-39-0
benzyl bromide

: 883443-06-9
(R)-4-[(1S,2S)-2-dibenzylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 16h; Heating / reflux;

Reference yield:

: 869527-91-3
1,3-difluoro-5-(2-nitroethyl)benzene

: 883443-06-9
(R)-4-[(1S,2S)-2-dibenzylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: nickel dichloride; sodium tetrahydroborate / methanol / 0.33 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 16 h / Reflux

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; potassium carbonate; nickel dichloride; In tetrahydrofuran; methanol; acetonitrile; 1: |Henry Nitro Aldol Condensation;
DOI:10.1021/acs.jmedchem.7b01304

Reference yield:

: 883439-27-8
tert-butyl (R)-4-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2,2-dimethyloxazolidine-3-carboxylate

: 883443-06-9
(R)-4-[(1S,2S)-2-dibenzylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: nickel dichloride; sodium tetrahydroborate / methanol / 0.33 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 16 h / Reflux

With sodium tetrahydroborate; potassium carbonate; nickel dichloride; In methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.7b01304