3-Benzyloxy-5-fluorobenzaldehyde

Base Information

• Chemical Name: 3-Benzyloxy-5-fluorobenzaldehyde
• CAS No.: 883443-39-8
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.239
• Mol file: 883443-39-8.mol

Synonyms:3-Benzyloxy-5-fluorobenzaldehyde;

Chemical Property of 3-Benzyloxy-5-fluorobenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 3.21720

Purity/Quality:

99% ^*data from raw suppliers

3-Benzyloxy-5-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzyloxy-5-fluorobenzaldehyde

There total 4 articles about 3-Benzyloxy-5-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-benzyloxy-5-fluoro-benzaldehyde (883443-39-8)

Guidance literature:

5-benzyloxy-3-fluorophenyl bromide; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 - 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

5-benzyloxy-3-fluorophenyl bromide (130722-44-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-benzyloxy-5-fluoro-benzaldehyde (883443-39-8)

Guidance literature:

5-benzyloxy-3-fluorophenyl bromide; With iodine; magnesium; In tetrahydrofuran; for 0.5h; Inert atmosphere; Reflux;

N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3-benzyloxy-5-fluoro-benzaldehyde (883443-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 20 - 40 °C

2.1: magnesium; iodine / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

2.2: 0.5 h / 0 - 20 °C / Inert atmosphere

With iodine; sodium hydride; magnesium; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

N,N-dimethyl-formamide

5-benzyloxy-3-fluorophenyl bromide

benzyl alcohol

3,5-difluorobromobenzene

Downstream raw materials:

1-benzyloxy-3-fluoro-5-((E)-2-nitro-vinyl)-benzene