1-(Benzyloxy)-3-bromo-5-fluorobenzene

Base Information

• Chemical Name: 1-(Benzyloxy)-3-bromo-5-fluorobenzene
• CAS No.: 130722-44-0
• Molecular Formula: C13H10BrFO
• Molecular Weight: 281.124
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID40460285
• Nikkaji Number: J1.679.679D
• Wikidata: Q82284284
• Mol file: 130722-44-0.mol

Synonyms:1-(Benzyloxy)-3-bromo-5-fluorobenzene;130722-44-0;1-(Benzyloxy)-5-bromo-3-fluorobenzene;1-bromo-3-fluoro-5-phenylmethoxybenzene;Benzene, 1-bromo-3-fluoro-5-(phenylmethoxy)-;3-benzyloxy-1-bromo-5-fluorobenzene;SCHEMBL2226602;3-benzyloxy-5-fluorobromobenzene;DTXSID40460285;O-benzyl-3-bromo-5-fluorophenol;GNKNCAKNJIQBSX-UHFFFAOYSA-N;5-benzyloxy-3-fluorophenyl bromide;3-benzyloxy-1-bromo-5-flurobenzene;benzyl 3-bromo-5-fluorophenyl ether;1-Bromo-3-benzyloxy-5-fluorobenzene;1-Bromo-3-fluoro-5-benzyloxybenzene;MFCD13181618;1-benzyloxy-3-bromo-5-fluoro-benzene;1-bromo-3-fluoro-5-benzyloxy-benzene;AKOS016003896;AS-66236;CS-0037169;A888683;J-503498

Chemical Property of 1-(Benzyloxy)-3-bromo-5-fluorobenzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.16720
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 279.98991
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

97% ^*data from raw suppliers

1-(Benzyloxy)-3-bromo-5-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC(=CC(=C2)Br)F

Technology Process of 1-(Benzyloxy)-3-bromo-5-fluorobenzene

There total 6 articles about 1-(Benzyloxy)-3-bromo-5-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,5-difluorobromobenzene (461-96-1) + benzyl alcohol (100-51-6,185532-71-2) → 5-benzyloxy-3-fluorophenyl bromide (130722-44-0)

Guidance literature:

benzyl alcohol; With sodium hydride; In tetrahydrofuran; for 1h;

3,5-difluorobromobenzene; In tetrahydrofuran; at 20 ℃; for 49h;

Reference yield: 97.8%

3-bromo-5-fluorophenol (433939-27-6) + benzyl bromide (100-39-0) → 5-benzyloxy-3-fluorophenyl bromide (130722-44-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 83.0%

→ 5-benzyloxy-3-fluorophenyl bromide (130722-44-0)

Guidance literature:

upstream raw materials:

3,5-difluorobromobenzene

benzyl alcohol

N-Bromosuccinimide

4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran

Downstream raw materials:

5-benzyloxy-3,4'-difluorostilbene

3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane

4-(3-Benzyloxy-5-fluorophenyl)-4-hydroxytetrahydropyran

3-benzyloxy-5-fluoro-benzaldehyde