Technology Process of Benzaldehyde, 4,5-dichloro-2-methoxy-
There total 2 articles about Benzaldehyde, 4,5-dichloro-2-methoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
1,2-dimethoxyethane;
at 20 - 30 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanesulfonic acid / 105 °C
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
methanesulfonic acid; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01153
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: dichloromethane / 20 °C
2.1: sodium hydride / dimethyl sulfoxide / 20 °C
2.2: 20 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C
5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C
6.1: hydrazine hydrate / ethanol / 3 h / Reflux
7.1: triethylamine / dichloromethane / 0.5 h / 20 °C
8.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere
9.1: triethylamine / dichloromethane / 0.5 h / 20 °C
10.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation
11.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate
With
sodium tetrahydroborate; hydrazine hydrate; boron tribromide; sodium hydride; diisobutylaluminium hydride; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
5.1: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b01153
