Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate

Base Information

Chemical Name:Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate
CAS No.:88369-67-9
Molecular Formula:C16H17N3O3
Molecular Weight:299.329
Hs Code.:
DSSTox Substance ID:DTXSID40521567
Wikidata:Q82386111

Synonyms:88369-67-9;Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate;DTXSID40521567

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:299.12699141
Heavy Atom Count:22
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)NC1=C(N=CC=C1)N(C2=CC=CC=C2)C(=O)C

Technology Process of Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate

There total 4 articles about Ethyl {2-[acetyl(phenyl)amino]pyridin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 88369-65-7
2-anilino-3-ethoxycarbonylaminopyridine

: 75-36-5
acetyl chloride

: 88369-67-9
2-(N-acetyl-N-phenyl)amino-3-ethoxycarbonylaminopyridine

Guidance literature:: With triethylamine; In toluene; for 8h; Ambient temperature;

Reference yield:

: 6298-19-7
2-chloro-3-aminopyridine

: 88369-67-9
2-(N-acetyl-N-phenyl)amino-3-ethoxycarbonylaminopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 40percent aq. HBr / bis-(2-hydroxy-ethyl) ether / 5 h / 170 °C

2: 90 percent / triethylamine / tetrahydrofuran / 12 h / Ambient temperature

3: 75 percent / triethylamine / toluene / 8 h / Ambient temperature

With hydrogen bromide; triethylamine; In tetrahydrofuran; toluene; diethylene glycol;

Reference yield:

: 62-53-3
aniline

: 88369-67-9
2-(N-acetyl-N-phenyl)amino-3-ethoxycarbonylaminopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 40percent aq. HBr / bis-(2-hydroxy-ethyl) ether / 5 h / 170 °C

2: 90 percent / triethylamine / tetrahydrofuran / 12 h / Ambient temperature

3: 75 percent / triethylamine / toluene / 8 h / Ambient temperature

With hydrogen bromide; triethylamine; In tetrahydrofuran; toluene; diethylene glycol;