3972-81-4

Usage

Chemical classification

The compound belongs to the acetamide family, which is a group of organic compounds containing a carbonyl group attached to an amine group.

Molecular structure

The compound has a phenylethyl group (C6H5-CH2-CH3) attached to the nitrogen atom, and a dimethoxyphenyl group (C6H3-OCH3) attached to the carbon atom.

Usage

The compound is used in research and scientific experiments for its potential pharmaceutical applications, particularly in the study of its effects on the central nervous system and pain management.

Safety precautions

It is important to handle 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide with care and follow safety guidelines when working with it in a laboratory setting.

InChI:InChI=1/C18H21NO3/c1-21-16-9-8-15(12-17(16)22-2)13-18(20)19-11-10-14-6-4-3-5-7-14/h3-9,12H,10-11,13H2,1-2H3,(H,19,20)

Upstream product

• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 64-04-0 phenethylamine 
• 81316-62-3 ethyl 2-(3,4-dimethoxyphenyl)acetoimidate hydrochloride 
• 7568-93-6 2-Amino-1-phenylethanol 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 81316-50-9 2-<(3,4-dimethoxyphenyl)methyl>-5-phenyl-2-oxazoline 

Downstream Products

• 21965-92-4 1-(3',4'-dimethoxybenzyl)isoquinoline 
• 1198094-18-6 3-[N-(2-phenylethyl)amino]-6,7-dimethoxy-1-isopropylisoquinoline 
• 1198094-13-1 3-[N-(2-phenylethyl)amino]-6,7-dimethoxy-1-methylisoquinoline 
• 1198094-16-4 3-[N-(2-phenylethyl)amino]-6,7-dimethoxy-1-ethylisoquinoline 
• 88422-82-6 1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline 
• 70045-30-6 1-(3',4'-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 63925-47-3 N-(2-phenylethyl)-2-(3,4-dimethoxyphenyl)ethylamine 

Relevant academic research and scientific papers

A simple highly regioselective or regiospecific substitution method of aromatic isoquinoline

A novel simple version for highly regioselective or regiospecific substitution method of aromatic isoquinoline has been developed by utilizing the reaction condition of Bischler-Napieralski cyclization. The proposed reaction mechanism was successfully ind

A highly convenient, efficient, and selective process for preparation of esters and amides from carboxylic acids using Fe3+-K-10 montmorillonite clay

In the presence of Fe3+-K-10 montmorillonite clay as a catalyst, aliphatic carboxylic acids selectively produced the corresponding esters in the presence of aromatic carboxylic acids by treatment with alcohols. Both the aliphatic and aromatic carboxylic acids formed the amides by reacting with the aliphatic amines, but only the aliphatic carboxylic acids yielded the anilides by treatment with aromatic amines. The catalyst is recoverable and recyclable.

Inhibition of dopamine receptors by endogenous amines: Binding to striatal receptors and pharmacological effects on locomotor activity

Endogenous amine 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) derivatives are synthesized, and their activity for dopaminergic systems are evaluated in vitro and in vivo by receptor binding assay and pharmacological tests. It is proposed that 1BnTIQ d

Substituted isoquinolines and methods of using same

Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted isoquinolines exhibit activity in antagonizing the effects of platelet activating factor (PAF).

Oxazolines. 2. 2-Substituted 2-Oxazolines as Synthons for N-(β-Hydroxyethyl)arylalkylamines, Intermediates in a Synthesis of 1,2,3,4-Tetrahydroisoquinolines and 2,3,4,5-Tetrahydro-1H-3-Benzazepines

2-(Arylalkyl)-2-oxazolines 4 (n = 1) and 2-aryl-2-oxazolines 4 (n = 0), the latter prepared in a novel reaction by cross-coupling aryl Grignard reagents with 2-(methylthio)-5-phenyl-2-oxazoline (10) and using palladium(II) chloride (14) as a catalyst, were reduced in a previously unreported reaction by diborane in refluxing THF to yield N-(β- hyroxyethyl)arylalkylamines 5 (n = 1,2).Amino alcohols 5 were cyclized to their respective heterocyclic derivatives 6 (n = 1,2) by treatment with H2SO4/TFA in refluxing methylene chloride.This paper disscuses how 2-substituted 2-oxazolines may be used to prepare1,2,3,4-tetrahydroisoquinolines 6 (n = 1) and 2,3,4,5-tetrahydro-1H-3-benzazepines 6 (n = 2) via amino alcohols 5.

The mechanism of the Bischler-Napieralski Reaction

The Bischler-Napieralski dihydroisoquinoline synthesis was proven to occur via imidoyl chlorides and the corresponding nitrilium salt.Two-step process required much milder conditions (20 degC - 50 degC) compared to drastic classical conditions of refluxing at 100 degC - 200 degC.The Bischler-Napieralski reaction is shown to share a common intermediate with two other well-known reactions: the von Braun and the Ritter reactions