3-BENZENESULFONYLTHIOPHENE

Base Information

• Chemical Name: 3-BENZENESULFONYLTHIOPHENE
• CAS No.: 16718-05-1
• Molecular Formula: C10H8O2S2
• Molecular Weight: 224.2993
• Hs Code.: 2934999090
• Mol file: 16718-05-1.mol

Synonyms:3-Benzenesulphonylthiophene;

Chemical Property of 3-BENZENESULFONYLTHIOPHENE

Chemical Property:

• Vapor Pressure: 5.5E-06mmHg at 25°C
• Melting Point: 115 °C
• Refractive Index: 1.615
• Boiling Point: 391.6 °C at 760 mmHg
• Flash Point: 190.6 °C
• PSA: 70.76000
• Density: 1.34g/cm³
• LogP: 3.66170
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(phenylsulfonyl)thiophene AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZENESULFONYLTHIOPHENE

There total 4 articles about 3-BENZENESULFONYLTHIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Bromothiophene (872-31-1) + sodium benzenesulfonate (873-55-2) → 3-(phenylsulfonyl)thiophene (16718-05-1)

Guidance literature:

sodium benzenesulfonate; With triethylsilane; nickel(II) bromide trihydrate; 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

3-Bromothiophene; In 1-methyl-pyrrolidin-2-one; at 105 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201701478

Reference yield: 72.0%

C4H3BrSZn*MgCl2 + benzenesulfonyl chloride (98-09-9) → 3-(phenylsulfonyl)thiophene (16718-05-1)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c4ob00638k

Reference yield: 66.0%

thiophene-3-sulfonyl chloride (51175-71-4) + phenylzinc(II) bromide (38111-44-3) → 3-(phenylsulfonyl)thiophene (16718-05-1)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c4ob00638k

upstream raw materials:

thiophene-3-sulfonyl chloride

phenylzinc(II) bromide

benzenesulfonyl chloride

3-Bromothiophene

Refernces

• 1、 Fu, Ying,Zhu, Wenbo,Zhao, Xingling,Huegel, Helmut,Wu, Zhouqiang,Su, Yuhu,Du, Zhengyin,Huang, Danfeng,Hu, Yulai. "CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides". supporting information. p. 4295 - 4299. Retrieved 2014/06/23.