2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Base Information

Chemical Name:2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol
CAS No.:88467-01-0
Molecular Formula:C₂₀H₂₆N₄O₄
Molecular Weight:386.451
Hs Code.:
DSSTox Substance ID:DTXSID30524623
Wikidata:Q82391618

Synonyms:88467-01-0;DTXSID30524623;2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol;2,6-bis(morpholinomethyl)-4-phenyl-5-hydroxypyrimidine 1-oxide

Suppliers and Price of 2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Chemical Property:

XLogP3:-0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:386.19540532
Heavy Atom Count:28
Complexity:467

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CC2=C(C(=NC(=[N+]2[O-])CN3CCOCC3)C4=CC=CC=C4)O

Technology Process of 2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

There total 4 articles about 2,6-Bis[(morpholin-4-yl)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 110-91-8,99108-56-2
morpholine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 88070-45-5
4-Phenyl-5-hydroxypyrimidine 1-Oxide

: 88467-01-0
2,6-Bis(morpholinomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: With triethylamine; In benzene; for 0.25h; Heating;
DOI:10.1007/BF00506891

Reference yield:

: 3438-48-0
4-phenylpyrimidine

: 88467-01-0
2,6-Bis(morpholinomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / 1.) 40percent HBr, H₂SO₄; 2.) sodium nitrite / H₂O / 1 h / 0 - 5 °C

2: 72 percent / sodium methoxide / methanol / 8 h / 180 °C / autoclave

3: 37 percent / m-chloroperbenzoic acid / acetone / 72 h / 20 °C

4: 61 percent / triethylamine / benzene / 0.25 h / Heating

With sulfuric acid; hydrogen bromide; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In methanol; water; acetone; benzene;
DOI:10.1007/BF00506891

Reference yield:

: 88070-43-3
5-Hydroxy-4-phenylpyrimidine

: 88467-01-0
2,6-Bis(morpholinomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / m-chloroperbenzoic acid / acetone / 72 h / 20 °C

2: 61 percent / triethylamine / benzene / 0.25 h / Heating

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In acetone; benzene;
DOI:10.1007/BF00506891