CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE

Base Information

• Chemical Name: CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE
• CAS No.: 885122-89-4
• Molecular Formula: C₁₆H₂₂O₂
• Molecular Weight: 246.349
• Hs Code.: 2914509090
• Mol file: 885122-89-4.mol

Synonyms:1-Propanone,1-cyclohexyl-3-(4-methoxyphenyl);CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE;

Chemical Property of CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE

Chemical Property:

• Vapor Pressure: 1.38E-05mmHg at 25°C
• Boiling Point: 367.3oC at 760 mmHg
• Flash Point: 153.2oC
• PSA: 26.30000
• Density: 1.031g/cm3
• LogP: 3.77720

Purity/Quality:

97% ^*data from raw suppliers

Cyclohexyl2-(4-methoxyphenyl)ethylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE

There total 8 articles about CYCLOHEXYL 2-(4-METHOXYPHENYL)ETHYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 1-cyclohexyl-3-(4-methoxyphenyl)propan-1-one (885122-89-4)

Guidance literature:

With zirconocene dichloride; (2-(1-methyl-1H-imidazol-2-yl)pyridine)NiCl₂; (4,4',4''-trimethyl-2,2':6',2''-terpyridine)NiI; zinc powder; In 1,2-dimethoxyethane; N,N-dimethyl acetamide; at 20 ℃; for 3h; Inert atmosphere; Glovebox;

Reference yield: 86.0%

4-methoxyphenylboronic acid (5720-07-0) + 1-cyclohexylcyclopropan-1-ol (112650-62-1) → 1-cyclohexyl-3-(4-methoxyphenyl)propan-1-one (885122-89-4)

Guidance literature:

With copper diacetate; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In water; dimethyl sulfoxide; at 70 ℃; for 2h; chemoselective reaction;

DOI:10.1021/acs.joc.0c00160

Reference yield: 86.0%

3-(4-methoxyphenyl)propionyl chloride (15893-42-2) + 1-cyclohexyl-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt → 1-cyclohexyl-3-(4-methoxyphenyl)propan-1-one (885122-89-4)

Guidance literature:

With manganese; (2,2'-bipyridine)nickel(II) dibromide; In N,N-dimethyl acetamide; acetonitrile; at 20 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c00554

upstream raw materials:

Cyclohexyl methyl ketone

4-Methoxybenzyl alcohol

3-(4-methoxyphenyl)propionyl chloride

3-(4-methoxyphenyl)propanoic acid