5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one

Base Information

Chemical Name:5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one
CAS No.:88584-15-0
Molecular Formula:C12H9N3O2
Molecular Weight:227.222
Hs Code.:
DSSTox Substance ID:DTXSID40518558
Wikidata:Q82381293

Synonyms:88584-15-0;DTXSID40518558;5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one

Suppliers and Price of 5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:227.069476538
Heavy Atom Count:17
Complexity:350

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(C(=O)N1)N=C(O2)C3=CC=CC=C3

Technology Process of 5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one

There total 8 articles about 5-Methyl-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: methyl 5‐chlorosulfonyl‐2‐phenyl‐1,3‐oxazole‐4‐carboxylate

: 124-42-5
acetamidine hydrochloride

: 88584-15-0
5-Methyl-2-phenyl-6H-oxazolo[5,4-d]pyrimidin-7-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 65 ℃; for 25h;
DOI:10.1134/S1070363214080210

Reference yield:

: 54644-14-3
2-phenyl-5-ethoxyoxazole-4-carboxylic acid chloride

: 88584-15-0
5-Methyl-2-phenyl-6H-oxazolo[5,4-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / CH₂Cl₂ / 3 h / Ambient temperature

2: toluene / 1.5 h / Heating

3: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H₂O

With potassium hydroxide; sodium hydroxide; acetic acid; In dichloromethane; toluene;
DOI:10.1055/s-1983-30535

Reference yield:

: 54644-12-1
5-ethoxy-2-phenyloxazole-4-carboxylic acid

: 88584-15-0
5-Methyl-2-phenyl-6H-oxazolo[5,4-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / oxalyl chloride, DMF / CH₂Cl₂; diethyl ether / 2 h / Ambient temperature

2: aq. NaOH / CH₂Cl₂ / 3 h / Ambient temperature

3: toluene / 1.5 h / Heating

4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H₂O

With potassium hydroxide; sodium hydroxide; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; toluene;
DOI:10.1055/s-1983-30535