2-(4-Bromophenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:2-(4-Bromophenyl)pyrimidin-4(3H)-one
CAS No.:88627-12-7
Molecular Formula:C10H7BrN2O
Molecular Weight:251.082
Hs Code.:
DSSTox Substance ID:DTXSID80523080
Wikidata:Q82388885

Synonyms:88627-12-7;2-(4-bromophenyl)-1H-pyrimidin-6-one;2-(4-Bromophenyl)pyrimidin-4(3H)-one;2-(4-Bromophenyl)pyrimidin-4(1H)-one;DTXSID80523080;MFCD11878625;2-(p-bromophenyl)-4-hydroxypyrimidine;AKOS009844446;2-(4-bromophenyl)-3,4-dihydropyrimidin-4-one;A842732

Suppliers and Price of 2-(4-Bromophenyl)pyrimidin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(4-Bromophenyl)pyrimidin-4(3H)-one

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:249.97418
Heavy Atom Count:14
Complexity:291

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC=CC(=O)N2)Br

Technology Process of 2-(4-Bromophenyl)pyrimidin-4(3H)-one

There total 3 articles about 2-(4-Bromophenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 55368-42-8
4-bromobenzamidine hydrochloride

: sodium (E)-3-ethoxy-3-oxoprop-1-en-1-olate

: 88627-12-7
2-(p-bromophenyl)-4-hydroxypyrimidine

Guidance literature:: With sodium hydroxide; In ethanol; for 120h; Ambient temperature;
DOI:10.1007/BF00505770

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 88627-12-7
2-(4-bromophenyl)-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; chloroform / -65 - 20 °C

1.2: 20 h / 20 °C

2.1: sodium hydroxide / water

3.1: potassium hydroxide / ethanol / 60 - 80 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; In ethanol; chloroform; water;
DOI:10.1016/j.bmc.2012.02.006

Reference yield:

: 55368-42-8
4-bromobenzamidine hydrochloride

: 88627-12-7
2-(4-bromophenyl)-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water

2: potassium hydroxide / ethanol / 60 - 80 °C

With potassium hydroxide; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.bmc.2012.02.006