Phenol, 4-[3-(1H-pyrazol-1-yl)propyl]-, monohydrochloride

Base Information

• Chemical Name: Phenol, 4-[3-(1H-pyrazol-1-yl)propyl]-, monohydrochloride
• CAS No.: 88670-70-6
• Molecular Formula: C12H14N2O.ClH
• Molecular Weight: 238.717
• Mol file: 88670-70-6.mol

Synonyms:

Chemical Property of Phenol, 4-[3-(1H-pyrazol-1-yl)propyl]-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 4-[3-(1H-pyrazol-1-yl)propyl]-, monohydrochloride

There total 3 articles about Phenol, 4-[3-(1H-pyrazol-1-yl)propyl]-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxy)-α-<2-(1-pyrazolyl)ethyl>benzyl alcohol (80199-84-4) → 4-<3-(1-pyrazolyl)propyl>phenol hydrochloride (88670-70-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Yield given; Ambient temperature;

DOI:10.1021/jm00370a012

Reference yield:

1-(dimethylamino)-3-<4-(benzyloxy)phenyl>propan-3-one (51345-76-7) → 4-<3-(1-pyrazolyl)propyl>phenol hydrochloride (88670-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / butan-1-ol / 15 h / Heating

2: 98 percent / sodium borohydride / ethanol / 2 h

3: concd HCl, H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1021/jm00370a012

Reference yield:

4'-(benzyloxy)-3-(1-pyrazolyl)propiophenone (80199-83-3) → 4-<3-(1-pyrazolyl)propyl>phenol hydrochloride (88670-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / sodium borohydride / ethanol / 2 h

2: concd HCl, H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00370a012

upstream raw materials:

4-(benzyloxy)-α-<2-(1-pyrazolyl)ethyl>benzyl alcohol

1-(dimethylamino)-3-<4-(benzyloxy)phenyl>propan-3-one

4'-(benzyloxy)-3-(1-pyrazolyl)propiophenone

Downstream raw materials:

1-isopropylamino-3-[4-[3-(1-pyrazolyl)propyl]phenoxy]-2-propanol

Refernces