2-(4-Chlorophenyl)-6-methylquinazoline

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-6-methylquinazoline
• CAS No.: 88737-71-7
• Molecular Formula: C15H11ClN2
• Molecular Weight: 254.719
• DSSTox Substance ID: DTXSID90518563
• Wikidata: Q82381299

Synonyms:2-(4-Chlorophenyl)-6-methylquinazoline;88737-71-7;DTXSID90518563

Chemical Property of 2-(4-Chlorophenyl)-6-methylquinazoline

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 254.0610761
• Heavy Atom Count: 18
• Complexity: 276

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=CN=C(N=C2C=C1)C3=CC=C(C=C3)Cl

Technology Process of 2-(4-Chlorophenyl)-6-methylquinazoline

There total 5 articles about 2-(4-Chlorophenyl)-6-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Cyanochlorobenzene (623-03-0) + 2-amino-5-methylbenzyl alcohol (34897-84-2) → 2-(4-chlorophenyl)-6-methylquinazoline (88737-71-7)

Guidance literature:

With (6,8,15,17-tetramethyldibenzo[b,i][1,4,8,11]-tetraazacyclotetradecinato)nickel(II); potassium tert-butylate; In 5,5-dimethyl-1,3-cyclohexadiene; at 100 ℃; for 24h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1021/acs.joc.8b01479

Reference yield: 75.0%

4-Chloro-N-[1-dimethylamino-meth-(E)-ylidene]-N'-p-tolyl-benzamidine (88737-80-8) → 2-(4-chlorophenyl)-6-methylquinazoline (88737-71-7)

Guidance literature:

With PPA; at 130 - 150 ℃;

DOI:10.1016/S0040-4039(00)88339-2

Reference yield: 74.0%

2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8) + p-toluidine (106-49-0,12221-03-3) + dimethyl sulfoxide (67-68-5,8070-53-9) → 2-(4-chlorophenyl)-6-methylquinazoline (88737-71-7)

Guidance literature:

With hydrogen iodide; In water; at 140 ℃; for 18h; Sealed tube;

DOI:10.1039/d1cc00623a

upstream raw materials:

4-Chloro-N-[1-dimethylamino-meth-(E)-ylidene]-N'-p-tolyl-benzamidine

4-Chloro-N-p-tolyl-benzamidine

4-Cyanochlorobenzene

2-amino-5-methylbenzyl alcohol

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