hydroxy(phenyl)thiophen-3-ylacetic acid

Base Information

• Chemical Name: hydroxy(phenyl)thiophen-3-ylacetic acid
• CAS No.: 3193-25-7
• Molecular Formula: C12H10 O3 S
• Molecular Weight: 234.276
• Mol file: 3193-25-7.mol

Synonyms:3-Thiopheneglycolicacid, a-phenyl- (7CI,8CI);(Thiophen-3-yl)mandelic acid; NSC 149727

Chemical Property of hydroxy(phenyl)thiophen-3-ylacetic acid

Chemical Property:

• Vapor Pressure: 7.2E-08mmHg at 25°C
• Boiling Point: 421.8°Cat760mmHg
• Flash Point: 208.9°C
• Density: 1.396g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hydroxy(phenyl)thiophen-3-ylacetic acid

There total 4 articles about hydroxy(phenyl)thiophen-3-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetate (1415971-13-9) → 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetic acid (3193-25-7)

Guidance literature:

ethyl 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetate; With water; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 24h;

With hydrogenchloride; In water; at 20 ℃; pH=1;

Reference yield:

1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione (135490-84-5) → 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetic acid (3193-25-7)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01107a045

Reference yield:

phenylglyoxylic acid ethyl ester (1603-79-8) → 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetic acid (3193-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 24 h / 60 °C

2.2: 20 °C / pH 1

With water; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione

phenylglyoxylic acid ethyl ester

ethyl 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetate

Downstream raw materials:

3-benzoylthiophene

tert-butyl 4-((2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetyloxy)methyl)piperidine-1-carboxylate

(piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate