(piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate

Base Information

• Chemical Name: (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate
• CAS No.: 1415971-20-8
• Molecular Formula: C₇H₈O₃S*C₁₈H₂₁NO₃S
• Molecular Weight: 503.64
• Mol file: 1415971-20-8.mol

Synonyms:(piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate

Chemical Property of (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate

There total 5 articles about (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-((2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetyloxy)methyl)piperidine-1-carboxylate (1415971-18-4) + toluene-4-sulfonic acid (104-15-4) → (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate (1415971-20-8)

Guidance literature:

In acetonitrile; at 30 ℃;

Reference yield:

phenylglyoxylic acid ethyl ester (1603-79-8) → (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate (1415971-20-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 24 h / 60 °C

2.2: 20 °C / pH 1

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide; toluene / 100 °C

4.1: acetonitrile / 30 °C

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → (piperidin-4-yl)methyl 2-(thiophene-3-yl)-2-hydroxy-2-phenylacetate tosylate (1415971-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 1,4-dioxane / 19.67 h / 0 - 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide; toluene / 100 °C

3: acetonitrile / 30 °C

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

tert-butyl 4-((2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetyloxy)methyl)piperidine-1-carboxylate

toluene-4-sulfonic acid

phenylglyoxylic acid ethyl ester

2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetic acid