Liarozole

Base Information

Chemical Name:Liarozole
CAS No.:115575-11-6
Molecular Formula:C₁₇H₁₃ClN₄
Molecular Weight:308.77
Hs Code.:
UNII:17NYD2210B,090Y06W08H,K0Q29TGV9Y
DSSTox Substance ID:DTXSID9048277
Nikkaji Number:J475.138H,J679.976K
Wikipedia:Liarozole
Wikidata:Q15633974
NCI Thesaurus Code:C1433
Pharos Ligand ID:S1GNRQXSCAWW
Metabolomics Workbench ID:153937
ChEMBL ID:CHEMBL389433
Mol file:115575-11-6.mol

Synonyms:liarozole;liarozole fumarate;liarozole monohydrochloride;Liazal;R 085246;R 61405;R 75251;R-085246;R-61405;R-75251;R085246

Suppliers and Price of Liarozole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of Liarozole

Chemical Property:

Vapor Pressure:9.2E-13mmHg at 25°C
Melting Point:108.2°
Boiling Point:578.2°Cat760mmHg
Flash Point:303.5°C
PSA：46.50000
Density:1.36g/cm³
LogP:4.05050
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:308.0828741
Heavy Atom Count:22
Complexity:380

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4
Recent ClinicalTrials:Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis
Recent EU Clinical Trials:A randomized, double-blind, multinational, multicenter, placebo-controlled parallel phase II/III trial to evaluate the efficacy and safety of 2 doses of oral liarozole (75 mg o.d. and 150 mg o.d.) given during 12 weeks in comparison with placebo in the treatment of subjects with lamellar ichthyosis.
Uses Antipsoriatic.

Technology Process of Liarozole

There total 8 articles about Liarozole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64-18-6
formic acid

: 172282-46-1,736908-22-8,122558-90-1
4-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine

: 115575-11-6
liarozole

Guidance literature:: With hydrogenchloride; at 50 ℃; for 3h;
DOI:10.1016/S0960-894X(98)00004-3

Reference yield:

: 13389-51-0
(3-chlorophenyl)(4-methoxyphenyl)methanone

: 115575-11-6
liarozole

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / HNO₃ / 0.75 h / 10 °C

2: 76 percent / NH₃ / propan-2-ol / 16 h / 100 °C

3: 75 percent / NaBH₄ / propan-2-ol / 1 h / Heating

4: 69 percent / CH₂Cl₂ / 1 h / Heating

5: 54.3 percent / H₂, NH₃, thiophene / 5percent Pt/C / methanol

6: 86 percent / 4N aq. HCl / 3 h / 50 °C

With thiophene; hydrogenchloride; sodium tetrahydroborate; ammonia; hydrogen; nitric acid; platinum on activated charcoal; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/S0960-894X(98)00004-3

Reference yield:

: 66938-61-2
(4-amino-3-nitrophenyl)-3-chlorophenylmethanone

: 115575-11-6
liarozole

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaBH₄ / propan-2-ol / 1 h / Heating

2: 69 percent / CH₂Cl₂ / 1 h / Heating

3: 54.3 percent / H₂, NH₃, thiophene / 5percent Pt/C / methanol

4: 86 percent / 4N aq. HCl / 3 h / 50 °C

With thiophene; hydrogenchloride; sodium tetrahydroborate; ammonia; hydrogen; platinum on activated charcoal; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/S0960-894X(98)00004-3