3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol

Base Information

Chemical Name:3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol
CAS No.:88905-27-5
Molecular Formula:C15H21NO3
Molecular Weight:263.337
Hs Code.:
ChEMBL ID:CHEMBL346515
DSSTox Substance ID:DTXSID10534063

Synonyms:88905-27-5;3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol;CHEMBL346515;DTXSID10534063

Suppliers and Price of 3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:344

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CC2CC(C2(C1)C3=CC(=CC=C3)O)(OC)OC

Technology Process of 3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol

There total 5 articles about 3-(7,7-Dimethoxy-3-methyl-3-azabicyclo[3.2.0]heptan-1-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 88905-23-1
6,6-dimethoxy-5-(3-methoxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

: 88905-27-5
6,6-dimethoxy-5-(3-hydroxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

Guidance literature:: With sodium hydride; ethanethiol; In N,N-dimethyl-formamide; for 3h; Heating;
DOI:10.1021/jm00371a012

Reference yield:

: 930-88-1
N-methylmaleimide

: 88905-27-5
6,6-dimethoxy-5-(3-hydroxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 12 N aq. HCl, aq. NaNO₂, 2.) NaOAc, CuCl₂*2H₂O, 3.) 2,6-lutidine

2: 56 percent / K₂CO₃ / CH₂Cl₂ / Irradiation

3: 77 percent / NaAlH₂(OCH₂CH₂OCH₃)2 (Vitride-T) / toluene / 1.) RT, 0.5 h, 2.) reflux, 18 h

4: 49 percent / NaH, ethanethiol / dimethylformamide / 3 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; sodium acetate; sodium hydride; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; ethanethiol; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00371a012

Reference yield:

: 66504-57-2
2-(3-methoxyphenyl)-N-methylmaleimide

: 88905-27-5
6,6-dimethoxy-5-(3-hydroxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / CH₂Cl₂ / Irradiation

2: 77 percent / NaAlH₂(OCH₂CH₂OCH₃)2 (Vitride-T) / toluene / 1.) RT, 0.5 h, 2.) reflux, 18 h

3: 49 percent / NaH, ethanethiol / dimethylformamide / 3 h / Heating

With sodium hydride; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00371a012