5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one

Base Information

Chemical Name:5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one
CAS No.:88905-29-7
Molecular Formula:C14H17NO2
Molecular Weight:231.294
Hs Code.:
ChEMBL ID:CHEMBL157721
DSSTox Substance ID:DTXSID50604315

Synonyms:88905-29-7;CHEMBL157721;SCHEMBL10999845;DTXSID50604315;VDOONFHZSIUWEA-UHFFFAOYSA-N;5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one;3-methyl-5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one

Suppliers and Price of 5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:231.125928785
Heavy Atom Count:17
Complexity:330

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CC2CC(=O)C2(C1)C3=CC(=CC=C3)OC

Technology Process of 5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one

There total 5 articles about 5-(3-Methoxyphenyl)-3-methyl-3-azabicyclo[3.2.0]heptan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 88905-23-1
6,6-dimethoxy-5-(3-methoxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

: 88905-29-7
5-(3-methoxyphenyl)-3-azabicyclo<3.2.0>heptan-6-one

Guidance literature:: With hydrogenchloride; for 0.25h; Heating;
DOI:10.1021/jm00371a012

Reference yield:

: 66504-57-2
2-(3-methoxyphenyl)-N-methylmaleimide

: 88905-29-7
5-(3-methoxyphenyl)-3-azabicyclo<3.2.0>heptan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / CH₂Cl₂ / Irradiation

2: 77 percent / NaAlH₂(OCH₂CH₂OCH₃)2 (Vitride-T) / toluene / 1.) RT, 0.5 h, 2.) reflux, 18 h

3: 81 percent / 10percent aq. HCl / 0.25 h / Heating

With hydrogenchloride; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; toluene;
DOI:10.1021/jm00371a012

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 88905-29-7
5-(3-methoxyphenyl)-3-azabicyclo<3.2.0>heptan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 12 N aq. HCl, aq. NaNO₂, 2.) NaOAc, CuCl₂*2H₂O, 3.) 2,6-lutidine

2: 56 percent / K₂CO₃ / CH₂Cl₂ / Irradiation

3: 77 percent / NaAlH₂(OCH₂CH₂OCH₃)2 (Vitride-T) / toluene / 1.) RT, 0.5 h, 2.) reflux, 18 h

4: 81 percent / 10percent aq. HCl / 0.25 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; sodium acetate; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium nitrite; In dichloromethane; toluene;
DOI:10.1021/jm00371a012