Benzeneacetic acid, a-methyl-2-(2-thiazolyloxy)-

Base Information

Chemical Name:Benzeneacetic acid, a-methyl-2-(2-thiazolyloxy)-
CAS No.:88975-97-7
Molecular Formula:C₁₂H₁₁NO₃S
Molecular Weight:249.29
Hs Code.:

Synonyms:

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Chemical Property of Benzeneacetic acid, a-methyl-2-(2-thiazolyloxy)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Benzeneacetic acid, a-methyl-2-(2-thiazolyloxy)-

There total 10 articles about Benzeneacetic acid, a-methyl-2-(2-thiazolyloxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-(Thiazol-2-yloxy)-phenyl]-propionic acid methyl ester

: 88975-97-7
2-<2-(2-thiazolyloxy)phenyl>propionic acid

Guidance literature:: With sodium hydroxide; In methanol; at 40 ℃; for 3h; Yield given;
DOI:10.1248/cpb.31.3424

Reference yield:

: 65548-02-9
(+/-)-ethyl cyano(2-nitrophenyl)acetate

: 88975-97-7
2-<2-(2-thiazolyloxy)phenyl>propionic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

2: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

3: 89.8 percent / H₂ / 5percent Pd-C / ethanol

4: 1.) NaNO₂, H₂O/7.3percent H₂SO₄ / 1.) 0 deg C, 2 h; 2.) toluene, reflux, 15 min

5: triethylamine / diethyl ether / 2 h / -10 °C

6: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

7: 4.4 g / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

8: gaseous HCl / 3 h / 55 °C

9: 5percent aq NaOH / methanol / 3 h / 40 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen sulfide; water; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; palladium on activated charcoal; In methanol; diethyl ether; ethanol; acetic acid; acetone;
DOI:10.1248/cpb.31.3424

Reference yield:

: 88-73-3
2-Chloronitrobenzene

: 88975-97-7
2-<2-(2-thiazolyloxy)phenyl>propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 98.6 g / NaH / dimethylformamide / 24 h / 44 - 47 °C

2: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

3: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

4: 89.8 percent / H₂ / 5percent Pd-C / ethanol

5: 1.) NaNO₂, H₂O/7.3percent H₂SO₄ / 1.) 0 deg C, 2 h; 2.) toluene, reflux, 15 min

6: triethylamine / diethyl ether / 2 h / -10 °C

7: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

8: 4.4 g / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

9: gaseous HCl / 3 h / 55 °C

10: 5percent aq NaOH / methanol / 3 h / 40 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen sulfide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; palladium on activated charcoal; In methanol; diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.31.3424