2,3-Dichloro-4-iodopyridine

Base Information

• Chemical Name: 2,3-Dichloro-4-iodopyridine
• CAS No.: 889865-45-6
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.888
• Hs Code.: 2933399090
• Mol file: 889865-45-6.mol

Synonyms:2,3-dichlorine-4-iodopyridine;dichloroiodopyridine;Pyridine,2,3-dichloro-4-iodo;2,3-Dichloro-4-iodo-pyridine;

Chemical Property of 2,3-Dichloro-4-iodopyridine

Chemical Property:

• Melting Point: 109-113°C
• Boiling Point: 284.3±35.0 °C(Predicted)
• PKA: -0.80±0.10(Predicted)
• PSA: 12.89000
• Density: 2.129±0.06 g/cm3(Predicted)
• LogP: 2.99300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dichloro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,3-Dichloro-4-iodopyridine

There total 3 articles about 2,3-Dichloro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

2,3-dichloro-pyridine (2402-77-9) → 2,3-dichloro-4-iodopyridine (889865-45-6)

Guidance literature:

2,3-dichloro-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield: 44.0%

2,2,6,6-tetramethyl-piperidine (768-66-1) → 2,3-dichloro-4-iodopyridine (889865-45-6)

Guidance literature:

2,2,6,6-tetramethyl-piperidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

With 2,3-dichloro-pyridine; In diethyl ether; hexane; at -78 ℃; for 0.5h;

With iodine; In diethyl ether; hexane; at 20 ℃;

Reference yield: 42.0%

2,2,6,6-tetramethyl-piperidine (768-66-1) + 2,3-dichloro-pyridine (2402-77-9) → 2,3-dichloro-4-iodopyridine (889865-45-6)

Guidance literature:

2,2,6,6-tetramethyl-piperidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

2,3-dichloro-pyridine; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.018

upstream raw materials:

2,3-dichloro-pyridine

2,2,6,6-tetramethyl-piperidine

Downstream raw materials:

(S)-N-((S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-yl)-2-methylpropane-2-sulfinamide

1-(3-chloro-4-p-tolylpyridin-2-yl)hydrazine

8-chloro-7-p-tolyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

(3'-chloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl)hydrazine

Refernces

• 1、 -. "POLYSUBSTITUTED PYRIDINE COMPOUND, PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION". Paragraph 0122-0125. . Retrieved 2017/02/24.
• 2、 -. "NEW COMPOUNDS". Page/Page column 118. . Retrieved 2013/03/26.