2,3-Dichloropyridine

Base Information

• Chemical Name: 2,3-Dichloropyridine
• CAS No.: 2402-77-9
• Molecular Formula: C5H3Cl2N
• Molecular Weight: 147.992
• Hs Code.: 29333999
• European Community (EC) Number: 219-281-8
• NSC Number: 298535
• UNII: G8S8JY2HE2
• DSSTox Substance ID: DTXSID7051894
• Nikkaji Number: J51.303B
• Wikidata: Q72467875
• ChEMBL ID: CHEMBL4635484
• Mol file: 2402-77-9.mol

Synonyms:2,3-dichloropyridine

Chemical Property of 2,3-Dichloropyridine

Chemical Property:

• Appearance/Colour: White to slightly beige crystalline powder
• Vapor Pressure: 0.679mmHg at 25°C
• Melting Point: 64-67 °C(lit.)
• Refractive Index: 1.553
• Boiling Point: 192.5 °C at 760 mmHg
• PKA: -0.63±0.10(Predicted)
• Flash Point: 87.5 °C
• PSA: 12.89000
• Density: 1.388 g/cm³
• LogP: 2.38840
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: slightly soluble
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.9642545
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)Cl
• Uses: 2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.

Technology Process of 2,3-Dichloropyridine

There total 49 articles about 2,3-Dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

2,3,4,6-Tetrachloropyridine (14121-36-9) → 2,3-dichloro-pyridine (2402-77-9)

Guidance literature:

With hydrogen; triethylamine; urea; citric acid; In ethyl acetate; at 50 ℃; for 7h; under 7500.75 Torr; Solvent; Temperature; Pressure; Reagent/catalyst; Autoclave;

Reference yield: 98.0%

2,3,6-trichloropyridine (6515-09-9) → 2,3-dichloro-pyridine (2402-77-9)

Guidance literature:

With carbonylhydridetris(triphenylphosphine)rhodium(I); hydrogen; triethylamine; In methanol; at 60 ℃; under 450045 Torr; Temperature; Solvent; Pressure; Autoclave;

Reference yield: 96.3%

2,6-dichloropyridine (2402-78-0) → 2,3-dichloro-pyridine (2402-77-9) + 2,6-difluoro pyridine (1513-65-1)

Guidance literature:

In dimethyl sulfoxide;

upstream raw materials:

2-chloro-3-aminopyridine

5,6-dichloronicotinic acid

3-Chloropyridine

acetyl hypofluorite

Downstream raw materials:

2-butoxy-3-chloro-pyridine

1-(3-chloro-2-pyridyl)piperazine

2-phenylselenenyl,3-chloropyridine

2,3-bis(phenylselenenyl)pyridine

Refernces

• 1、 -. "Method for preparing 2, 3 -dichloropyridine from chlorination". Paragraph 0032; 0055-0057. . Retrieved 2021/11/03.
• 2、 -. "Preparation method of 2, 3-dichloropyridine". Paragraph 0015-0026. . Retrieved 2021/04/03.