2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Base Information

• Chemical Name: 2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl
• CAS No.: 1152617-71-4
• Molecular Formula: C₁₆H₁₅Cl₂FN₂
• Molecular Weight: 325.213
• Mol file: 1152617-71-4.mol

Synonyms:2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Chemical Property of 2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

There total 1 articles about 2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2,3-dichloro-4-iodopyridine (889865-45-6) + 4-fluoro-4-phenylpiperidine hydrochloride (1056382-25-2) → 2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl (1152617-71-4)

Guidance literature:

2,3-dichloro-4-iodopyridine; 4-fluoro-4-phenylpiperidine hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 110 ℃; for 6h; sealed tube;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield: 84.0%

2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl (1152617-71-4) → (3'-chloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl)hydrazine (1254981-22-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 160 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl (1152617-71-4) → 2-amino-3-chloro-4-(4'-fluoro-4'-phenyl)piperidinylpyridine (1152617-73-6)

Guidance literature:

2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl; With Benzophenone imine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 ℃; for 16h; sealed tube;

With hydroxylamine hydrochloride; triethylamine; In methanol; toluene; for 5h;

upstream raw materials:

2,3-dichloro-4-iodopyridine

4-fluoro-4-phenylpiperidine hydrochloride

Downstream raw materials:

2-amino-3-chloro-4-(4'-fluoro-4'-phenyl)piperidinylpyridine

(3'-chloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl)hydrazine

Refernces

• 1、 -. "1,2,3-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS". Page/Page column 102. . Retrieved 2010/12/17.