1,3-ADAMANTANEDIAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1,3-ADAMANTANEDIAMINE DIHYDROCHLORIDE
• CAS No.: 26562-81-2
• Molecular Formula: C10H20Cl2N2
• Molecular Weight: 239.188
• Hs Code.: 2921300090
• Mol file: 26562-81-2.mol

Synonyms:1,3-Adamantanediamine,dihydrochloride (6CI,7CI,8CI);Tricyclo[3.3.1.13,7]decane-1,3-diamine,dihydrochloride (9CI);1,3-Diaminoadamantane dihydrochloride;Adamantane-1,3-diamine dihydrochloride;

Chemical Property of 1,3-ADAMANTANEDIAMINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0241mmHg at 25°C
• Melting Point: 308-350 °C (decomp)(Solv: acetone (67-64-1); water (7732-18-5))
• Boiling Point: 248.6 °C at 760 mmHg
• Flash Point: 122 °C
• PSA: 52.04000
• LogP: 3.99980
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Adamantane-1,3-diamine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-ADAMANTANEDIAMINE DIHYDROCHLORIDE

There total 2 articles about 1,3-ADAMANTANEDIAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N'-(adamantane-1,3-diyl)diacetamide (59940-35-1) → adamantane-1,3-bis(aminium) dichloride (26562-81-2)

Guidance literature:

With hydrogenchloride; water; for 25h; Reflux;

DOI:10.1134/S1070428017080024

Reference yield:

adamantane (281-23-2) → adamantane-1,3-bis(aminium) dichloride (26562-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nitric acid / 1 h / 25 °C

1.2: 0.5 h

1.3: 10 h / 20 °C

2.1: hydrogenchloride; water / 25 h / Reflux

With hydrogenchloride; water; nitric acid; 1.3: |Ritter Amidation;

DOI:10.1134/S1070428017080024

Reference yield: 63.0%

adamantane-1,3-bis(aminium) dichloride (26562-81-2) + 4-methoxy-benzoyl chloride (100-07-2) → N-(3-amino-1-adamantyl)-4-methoxybenzamide

Guidance literature:

With PS-DIEA; In dichloromethane; at 0 ℃; for 24h; Polystyrene

upstream raw materials:

N,N'-(adamantane-1,3-diyl)diacetamide

adamantane

Downstream raw materials:

N-(3-amino-1-adamantyl)glycine benzyl ester

Refernces