2-Propenoic acid, 3-(4-methoxyphenyl)-, 4-nitrophenyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-methoxyphenyl)-, 4-nitrophenyl ester, (E)-
• CAS No.: 89023-01-8
• Molecular Formula: C16H13NO5
• Molecular Weight: 299.283
• Mol file: 89023-01-8.mol

Synonyms:(E)-3-(4-Methoxy-phenyl)-acrylic acid 4-nitro-phenyl ester;4-nitrophenyl 4-methoxycinnamate;p'-nitrophenyl p-methoxycinnamate;p-nitrophenyl 4-methoxycinnamate;4-methoxycinnamic acid p-nitrophenyl ester;

Chemical Property of 2-Propenoic acid, 3-(4-methoxyphenyl)-, 4-nitrophenyl ester, (E)-

Chemical Property:

• PSA: 81.35000
• LogP: 3.74540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-(4-methoxyphenyl)-, 4-nitrophenyl ester, (E)-

There total 2 articles about 2-Propenoic acid, 3-(4-methoxyphenyl)-, 4-nitrophenyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → p-nitrophenyl ester of 4-methoxycinnamic acid (89023-01-8)

Guidance literature:

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; at 20 - 25 ℃; for 1h;

DOI:10.1016/j.tet.2020.131758

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (E)-3-(4-methoxyphenyl)propenoyl chloride (34446-64-5,42996-84-9) → p-nitrophenyl ester of 4-methoxycinnamic acid (89023-01-8)

Guidance literature:

In pyridine; warming 1h, standing overnight;

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + p-nitrophenyl ester of 4-methoxycinnamic acid (89023-01-8) → C14H17NO3 (321689-62-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 4h;

upstream raw materials:

4-nitro-phenol

(E)-3-(4-methoxyphenyl)propenoyl chloride

(E)-3-(4-methoxyphenyl)acrylic acid

Downstream raw materials:

4'-methoxy cinnamoyl duocarmycin SA

C₂₄H₂₂N₂O₅

C₂₂H₂₀N₂O₃