2-Chloro-4-methyl-3-phenylquinoline

Base Information

Chemical Name:2-Chloro-4-methyl-3-phenylquinoline
CAS No.:89081-06-1
Molecular Formula:C16H12ClN
Molecular Weight:253.731
Hs Code.:
DSSTox Substance ID:DTXSID90554002
Wikidata:Q82434783

Synonyms:2-chloro-4-methyl-3-phenylquinoline;89081-06-1;SCHEMBL1787324;DTXSID90554002;DYSUHDOSVZCJEW-UHFFFAOYSA-N

Suppliers and Price of 2-Chloro-4-methyl-3-phenylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Chloro-4-methyl-3-phenylquinoline

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:253.0658271
Heavy Atom Count:18
Complexity:274

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC2=CC=CC=C12)Cl)C3=CC=CC=C3

Technology Process of 2-Chloro-4-methyl-3-phenylquinoline

There total 2 articles about 2-Chloro-4-methyl-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19069-84-2
4-methyl-3-phenylquinolin-2(1H)-one

: 89081-06-1
2-chloro-4-methyl-3-phenylquinoline

Guidance literature:: With trichlorophosphate; for 2h; Heating;
DOI:10.1021/jm00395a013

Reference yield:

: 41296-66-6
2'-acetyl-1-phenylacetanilide

: 89081-06-1
2-chloro-4-methyl-3-phenylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Na / toluene / 1 h / Heating

2: POCl₃ / 2 h / Heating

With sodium; trichlorophosphate; In toluene;
DOI:10.1021/jm00395a013

Reference yield: 78.0%

: 654655-76-2
1-(3,5-difluorophenyl)-3-(dimethylamino)prop-1-one

: 89081-06-1
2-chloro-4-methyl-3-phenylquinoline

: 861872-63-1
C₂₇H₂₅ClF₂N₂O

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -20 ℃; for 0.5h;

2-chloro-4-methyl-3-phenylquinoline; In tetrahydrofuran; at -70 ℃; for 0.75h;

1-(3,5-difluorophenyl)-3-(dimethylamino)prop-1-one; In tetrahydrofuran; at -70 ℃; for 2h;